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ProteomicsHuman cerebrospinal fluid analysis by data-independent analysis The Cerebrospinal fluid samples were denaturated and reduced.
Cerebrospinal fluid samples of patients with Parkinson’s disease and healthy controls were used in this study. After tryptic digestion, all samples were spiked with indexed retention time (iRT) peptides and were measured using a DIA mass spectrometry approach.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022234 | Pride
Human Dia Cerebrospinal fluid Parkinsons disease 
UnknownNeoadjuvant chemotherapy improves outcomes in resectable pancreatic adenocarcinoma.
Not available
S-EPMC11749821 | biostudies-literature
UnknownTreatment Utilization and Outcomes for Locally Advanced Rectal Cancer in Older Patients.
Not available
S-EPMC9520439 | biostudies-literature
ProteomicsThe N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment
DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns. However, the mechanisms underlying DNMT3A recruitment to and function within different chromatin environments remain unclear. Using a combination of biochemical and structural approaches...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD056554 | Pride
Dnmt3a Udr Histone modifications Nucleosomes Chromatin 
TranscriptomicsMicroarray (one-color) gene expression analysis of Euglena gracilis subjected to altered acceleration during parabolic flight
Euglena gracilis is a unicellular freshwater flagellate, which uses the gravitational vector for orientation in the water column in the dark. This allows the cell to reach areas in the water column for reproduction and growth. How exactly the gravitational vector is perceived, and which intracellula...
ORGANISM(S): Euglena gracilis 
2019-07-09 | E-MTAB-8064 | biostudies-arrayexpress
UnknownMicroRNAs from extracellular vesicles as a signature for Parkinson's disease.
Not available
S-EPMC8021010 | biostudies-literature
ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
ProteomicsPhosphoproteomic Analysis of Mec1/ATR Signaling in Response to Different Manners of Kinase Activation
The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we employed a combined genetic-phospho...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-01-14 | PXD009734 | Pride
Atr Phosphoproteomics Mec1 Dna2 Dpb11 Ddc1 
ProteomicsMeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation
ethyl-CpG-binding protein 2 (MeCP2) is an epigenetic reader essential for neuronal function, but how it binds DNA methylation within chromatin is still unclear. Using designer nucleosomes we observe that MeCP2 preferentially binds DNA methylation positioned at multiple sites around the nucleosome. S...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD064826 | Pride
Mecp2 Cross-linking mass spectrometry Dna methylation Nucleosomes Chromatin 
ProteomicsTOPBP1 Shapes XY Silencing Dynamics Independently of Sex Body Formation to Ensure Male Fertility
In mammals and several other taxa, the ability of males to cope with the limited synapsis of the X and Y chromosomes during prophase I of meiosis relies on the process of meiotic sex chromosome inactivation (MSCI). Components of the somatic DNA damage response machinery, including ATR, TOPBP1, MDC1 ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-02-09 | PXD042199 | Pride
Topbp1 Male meiosis Mice Msci and xy silencing 
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