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MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
MetabolomicsGlobal ocean lipidomes show a universal relationship between temperature and lipid unsaturation

Global-scale surveys of plankton communities using “omics” techniques have revolutionized our understanding of the ocean. Lipidomics has demonstrated the potential to add further essential insights on ocean ecosystem function but has yet to be applied on a global scale. We analyzed 930 lipid samp...

2021-11-08 | MTBLS2838 | MetaboLights
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsPreferential phosphorylation on old histones during early mitosis in human cells
How histone posttranslational modifications (PTMs) are inherited through cell cycle remains poorly understood. Canonical histones are made in the S phase of cell cycle. Combining mass spectrometry-based technologies and stable isotope labeling by amino acids in cell culture (SILAC), we interrogate t...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003709 | Pride
Mass spectrometry Mitosis Histone modifications Cell cycle Histone phosphorylation 
ProteomicsQuantitative Live Cell Imaging Reveals Differential Manipulation of Rab11A Transport Pathways by Influenza virus and RSV
Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Using high spatiotemporal resolution light-shee...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/California/07/2009(H1N1)) 
2020-01-14 | PXD016331 | Pride
Live-cell imaging Rab11a Influenza virus Vesicle tracking Light-sheet microscopy Assembly Rna Microtubules Endosomes Fluorescence microscopy Viral rna Motor transport 
ProteomicsSurveying the vampire bat (Desmodus rotundus) serum proteome: a resource for identifying immunological proteins and detecting pathogens
Bats are increasingly studied as model systems for longevity and as natural hosts to some virulent viruses. Yet our ability to characterize immune mechanisms of viral tolerance and to quantify infection dynamics in wild bats is often limited by small sample volumes and few species-specific reagents....
ORGANISM(S): Desmodus rotundus 
2020-12-07 | PXD022885 | Pride
Lc-msms Dia Vampire bat Serum 
ProteomicsProteomic analysis of California sea lion urine
It is often necessary to demonstrate measurement capabilities in fields not already using state of the art bioanalytical platforms in order to encourage metrological modernization and adoption of such technologies. Marine mammal proteomics is a burgeoning field with diverse stakeholders and rapid in...
ORGANISM(S): Zalophus californianus (California sealion) 
2018-06-06 | PXD009019 | Pride
Marine mammal Urine California sea lion 
ProteomicsProteomic analysis of six different tissues from the Atlantic bottlenose dolphin (Tursiops truncatus)
Proteomic analysis of six tissues (liver, kidney, blubber, brain, muscle, skin) provided experimental confirmation of 10,402 proteins from 4,711 protein groups, almost 1/3 of the possible predicted proteins in the Atlantic bottlenose dolphin (Tursiops truncatus) NCBI annotation (release 101), which ...
ORGANISM(S): Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) 
2018-02-09 | PXD008808 | Pride
Brain Skin Liver Kidney Atlantic bottlenose dolphin Blubber Tursiops truncatus Muscle 
ProteomicsThe Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly
Paramyxoviruses are negative sense single-stranded RNA viruses that comprise many important human and animal pathogens, including human parainfluenza viruses. These viruses bud from the plasma membrane of infected cells after the viral ribonucleoprotein complex (vRNP) is transported from the cytopla...
ORGANISM(S): Homo sapiens (Human) Murine respirovirus 
2020-08-06 | PXD019637 | Pride
Rab11a Sendai virus cantell A549 cells 
ProteomicsIdentification of candidate protein biomarkers associated with domoic acid toxicosis in cerebrospinal fluid of California sea lions (Zalophus californianus)
Since 1998, California sea lion stranding events associated with domoic acid toxicosis (DAT) have consistently increased and there are no practical non-lethal clinical tests for the diagnosis of domoic acid toxicosis that can be utilized in a large-scale rehabilitation facility. Proteomic analysis w...
ORGANISM(S): Zalophus californianus (California sealion) 
2023-04-05 | PXD041356 | Pride
Cerebrospinal fluid Lc-msms California sea lion Domoic acid toxicosis 
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