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ProteomicsNicotinamide Mononucleotide Requires SIRT3 to Improve Cardiac Function and Bioenergetics in a Friedreich’s Ataxia Cardiomyopathy Model
Martin et al. JCI Insigh (2017). Increasing NAD+ levels by supplementing with the precursor nicotinamide mononucleotide (NMN) improves cardiac function in multiple mouse models of disease. While NMN influences several aspects of mitochondrial metabolism, the molecular mechanisms by which increased N...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-21 | PXD006754 | Pride
Nmn Friedreich’s ataxia Heart failure Sirt3 Acetylation 
MetabolomicsHeadspace volatile organic compounds from bacteria implicated in ventilator-associated pneumonia analysed by TD-GC/MS
Ventilator-associated pneumonia (VAP) is a healthcare-acquired infection arising from the invasion of the lower respiratory tract by opportunistic pathogens in ventilated patients. The current method of diagnosis requires the culture of an airway sample such as bronchoalveolar lavage, which is invas...
2018-08-08 | MTBLS497 | MetaboLights
ProteomicsSalt stress in freshwater anaerobic methane-oxidizing archaea
Maider J. Echeveste Medrano and colleagues characterized the physiological and metabolic response of freshwater methanotrophic archaea to salt stress. The study performed metaproteomics, gene expression profiles and dedicated metabolomics to identify the pathways involved in the salt stress response...
ORGANISM(S): Candidatus Methanoperedens nitroreducens 
2024-07-17 | PXD048239 | Pride
Salt stress Methane-oxidizing archaea Shotgun proteomics Metaproteomics 
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
UnknownRole of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group.
Not available
S-EPMC5015423 | biostudies-literature
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD001809 | Pride
Focal adhesions Integrin Extracellular matrix Msc Cell adhesion 
TranscriptomicsComparison of undifferentiated ES cell lines HM1, IMT11, SHBL6.3
3 different ES cell lines were compared in order to determine whether there are significant expression profile differences between ES cell lines, or whether the constraints of maintaining pluripotency in culture force a similar expression profile on cell lines derived from disparate sources. Our res...
ORGANISM(S): Mus musculus 
2007-08-03 | E-GEOD-8625 | biostudies-arrayexpress
ProteomicsProximity biotinylation of CDK1 associated proteins in U2OS cells
BirA ligase tagged CDK1 and BirA alone were expressed in U2OS cells. Proximal proteins to CDK1 were labelled by incubating cells with Biotin for 24 hours and biotinylated proteins extracted using Streptavidin pulldown.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD024796 | Pride
Human Lc-msms Proximity biotinylation Cdk1 
ProteomicsDefinition of the fibroblast adhesome using multiplexed proximity biotinylation
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry and topological organisation of proteins within IACs are not fully understood. To address ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD017241 | Pride
Fibroblast Adhesome Bioid 
ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo sapiens (Human) 
2016-02-02 | PXD002720 | Pride
Proteomics Ms Adhesion Focal adhesion kinase (fak) Integrin 
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