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ProteomicsSILAC-iPOND analysis of WT vs ATRX KO eHAP cells ± HU
Mutations in the ATRX chromatin remodeller predispose to a developmental genetic disorder and cancer, but how ATRX safeguards genome and telomere stability remains unresolved. Here, we uncover critical dependencies for the CTC1-STN1-TEN1 (CST) complex and RAD9A-HUS1-RAD1 (9-1-1) clamp in ATRX defici...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD068487 | Pride
ProteomicsPooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response
Microproteins encoded by short open reading frames (sORFs) of less than 100 codons have been predicted to constitute a substantial fraction of the eukaryotic proteome. However, relevance and roles of the majority of microproteins remain undefined because only a small fraction of these intriguing cel...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD058567 | Pride
Melanoma Integrated stress response Human Microprotein 
MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
TranscriptomicsDissecting the Mycobacterium bovis BCG response to macrophage infection to identify targets for anti-tuberculosis drug and vaccine discovery
New strategies are required to reduce the worldwide burden of tuberculosis. Intracellular survival and replication of Mycobacterium tuberculosis after macrophage phagocytosis is a fundamental step in the complex host-pathogen interactions that lead to granuloma formation and disease. Greater underst...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2022-01-14 | E-MTAB-11107 | biostudies-arrayexpress
UnknownOptimizing the clinical utility of four proposed criteria for a persistent and impairing grief disorder by emphasizing core, rather than associated symptoms.
Not available
S-EPMC7025160 | biostudies-literature
ProteomicsTumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presented to the immune system. Whilst the peptide ligandome prese...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD025345 | Pride
Cancer Extracellular vesicles T-cell epitopes Taa Hla class i ligandome Evs Tumour. Tumour-associated antigens 
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
ProteomicsIdentifying protein interactors of circACVR2A(2-4) in human cells
Differentiation of stem cells is driven by tightly coordinated transcriptional programs, yet the contribution of circular RNAs (circRNAs) to lineage specification remains poorly defined. We identified that depletion of circACVR2A(2–4), but not its linear counterpart, rapidly induced neuroectodermal ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD080807 | Pride
Human Lc-msms Stem cell Circular rna Cyclin h 
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
ProteomicsERG overexpression is a predictive biomarker for PARP-inhibitor-mediated selective radiosensitization in prostate cancer – a proof of concept study
Radiotherapy (RT) is a key treatment for prostate cancer (PCa), relying on the ability to induce DNA damage, particularly double-strand breaks (DSBs). The success of RT depends on tumor radiosensitivity and the ability to repair DSBs, making inhibitors of DSB repair enzymes a potential strategy for ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD060964 | Pride
Prostate cancer Erg overexpression Parp inhibition Dna double-strand break repair Radiotherapy 
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