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ProteomicsBudding yeast relies on qualitative G1 cyclin specificity to couple cell cycle progression with morphogenetic development
Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. In the qualitative model, cell cycle events are ordered by distinct substrate specificities associated with successive waves of G1, S and mitotic cyclins. Alternatively, the gradual quantitative rise of Cdk...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022757 | Pride
Lc-ms/ms Tmt Cdk Yeast Cyclin Cell cycle Phosphoproteomics Cyclin-dependent kinase 
ProteomicsThe CARD14E138A phosphoproteome
Psoriasis is a chronic inflammatory disease of the skin for which current treatments are only partially effective. There is therefore an urgent need to develop novel therapies with higher efficacy through a better understanding of disease aetiology. Recently, it has been demonstrated that individual...
ORGANISM(S): Homo sapiens (Human) 
2024-08-27 | PXD033009 | Pride
Carma Keratinocyte Malt1 Bcl10 Psoriasis Nf-kappab Card14 
ProteomicsThe CARD14WT/E138A interactome.
Psoriasis is a chronic inflammatory disease of the skin for which current treatments are only partially effective. There is therefore an urgent need to develop novel therapies with higher efficacy through a better understanding of disease aetiology. Recently, it has been demonstrated that individual...
ORGANISM(S): Homo sapiens (Human) 
2024-08-27 | PXD033039 | Pride
Carma Keratinocyte Malt1 Bcl10 Psoriasis Nf-kappab Card14 
ProteomicsOxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the large-scale mass-spectrometric quantification of glycopeptides in pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-29 | MSV000089567 | MassIVE
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