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ProteomicsCYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge
CYRI proteins promote lamellipodial dynamics by opposing Rac1-mediated activation of the Scar/WAVE complex. This activity also supports resolution of macropinocytic cups, promoting internalisation of surface proteins, including integrins. Here, we show that CYRI-B also promotes focal adhesion matu...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062975 | Pride
Vinculin Bio-id Integrins Actin cytoskeleton Erc1 Focal adhesions Paxillin Cyri-b Microtubules 
ProteomicsEffect of TPA on focal adhesion composition
Effect of a tumor promoter TPA on collagen IV based focal adhesions from CHO cells expressing human integrin alpha1 with activating mutation E317A
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2016-07-11 | PXD003153 | Pride
Focal adhesions Cho cells Lc-ms/ms 
ProteomicsPD-L1 intracellular interactions that necessitate the TSS motif within the cytoplasmic domain
Lymphatic endothelial cells (LEC) comprise lymphatic vessels that guide immune cells to lymph nodes (LN) and form the subcapsular sinus and cortical and medullary lymphatic structures of the LN. During an active immune response the lymphatics remodel to accommodate the influx of immune cells from th...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-01 | MSV000089579 | MassIVE
UnknownCell mechanosensitivity controls the anisotropy of focal adhesions.
Not available
S-EPMC515090 | biostudies-literature
OtherIntegrin endosomal signalling suppresses anoikis.
Data from ProteomeXchange, PXD ID: PXD001870. Experiment: Plasma membrane fraction R2 raw, file: 150120_106.mzml. Published as part of Nat Cell Biol. 2015 Oct 5 . From the Abstract: {{i}} Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell ...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310025155 | GPMDB
Resource Reanalysis 
ProteomicsCK2β is a gatekeeper of focal adhesions regulating cell spreading
CK2 is an hetero-tetrameric protein made of two CK2α catalytic subunits and two regulatory CK2β subunits. The free CK2α subunit and the tetrameric holoenzyme have distinct substrate specificity profiles suggesting that the spatiotemporal organization of the individual CK2 subunits observed in living...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD030991 | Pride
Proteomics Tyrosine phosphorylated proteins Ck2β depletion Lc-ms/ms 
UnknownInduction of focal adhesions and motility in Drosophila S2 cells.
Not available
S-EPMC4244196 | biostudies-literature
GenomicsWnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions
Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions
PRJNA780961 | ENA
UnknownEndothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling.
Not available
S-EPMC8167051 | biostudies-literature
UnknownThe KDEL receptor signalling cascade targets focal adhesion kinase on focal adhesions and invadopodia.
Not available
S-EPMC5828207 | biostudies-literature
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