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ProteomicsUnifying the analysis of bottom-up proteomics data with CHIMERYS
Proteomic workflows generate vastly complex peptide mixtures that are analyzed by liquid chromatography–tandem mass spectrometry, creating thousands of spectra, most of which are chimeric and contain fragment ions from more than one peptide. Because of differences in data acquisition strategies such...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Homo sapiens (Human) Mus musculus (Mouse) Halobacterium salinarum Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2025-04-16 | PXD053241 | Pride
Dia Human Fdr Chimerys Entrapment Multi-species Lc-msms Dda 
ProteomicsATLANTIC: Activity landscapes of tumor cell lines determine drug responses
Analysis of cancer cell line (CCL) genomes, proteomes and phenotypic drug responses are emerging approaches to uncover molecular mechanisms of drug action. We extended this paradigm to measuring proteome activity landscapes by integrating quantitative data for 10,000 proteins and 55,000 phosphorylat...
ORGANISM(S): Homo sapiens (Human) 
2020-07-27 | PXD013615 | Pride
Crc65 Pharmacoproteomics Nci60 Drug sensitivity Tumor cell lines 
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Kinobeads
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo sapiens (Human) 
2017-12-12 | PXD005355 | Pride
Personalised medicine Integrated full proteome subtypes Crc65 Mass spectrometry Correlation of mrna and protein abundance Patient stratification Consensus molecular subtypes Cptac Quasar2 Kinobeads 
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo sapiens (Human) 
2017-12-12 | PXD005354 | Pride
Personalised medicine Integrated full proteome subtypes Crc65 Mass spectrometry Correlation of mrna and protein abundance Patient stratification Consensus molecular subtypes Cptac Quasar2 Kinobeads 
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CPTAC Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD005353 | Pride
Personalised medicine Integrated full proteome subtypes Crc65 Mass spectrometry Correlation of mrna and protein abundance Patient stratification Consensus molecular subtypes Cptac Quasar2 Kinobeads 
ProteomicsGlobal Proteome Analysis of the NCI-60 Cell Line Panel, part 3
The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2017-09-25 | PXD005946 | Pride
Lc-ms/ms Nci60 Dtp 
ProteomicsGlobal Proteome Analysis of the NCI-60 Cell Line Panel
The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2017-03-31 | PXD005940 | Pride
Lc-ms/ms Nci60 Dtp 
ProteomicsGlobal Proteome Analysis of the NCI-60 Cell Line Panel, part 2
The NCI-60 cell line collection is a very widely used panel for the study of cellular mechanisms of cancer in general and in vitro drug action in particular. It is a model system for the tissue types and genetic diversity of human cancers and has been extensively molecularly characterized. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2017-03-31 | PXD005942 | Pride
Lc-ms/ms Nci60 Dtp 
ProteomicsChemical and phosphoproteomics illuminate the cellular mode of action of AKT inhibitors
Due to its key role in dysregulated cellular signaling in cancer, AKT has been subject to intense drug discovery efforts leading to small molecule inhibitors investigated in clinical trials, notably breast cancer. To shed more light on how these drugs exert their therapeutic effects, we integrated c...
ORGANISM(S): Homo Sapiens 
2022-01-21 | PXD015188 | panorama
ProteomicsPharmacoproteomic characterisation of human colon and rectal cancer - CRC65 Full Proteomes
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of >10,000 proteins using mass spectrometry. Integration with prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-23 | MSV000081738 | MassIVE
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