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TranscriptomicsSlug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU-treatment
In pancreatic cancer the survival rate is low, as the available treatment options usually only extend survival and seldom produce a cure. Drug resistance and disease reoccurrence is the typical reason for death after cancer diagnosis. 5-Fluorouracil (5-FU) is the main chemostatic used in first line ...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-58386 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of QUB HCT116 sensitive and resistant colorectal cancer time series
HCT116 parental, HCT116 5-FU resistant and HCT116 oxaliplatin resistant cells have been transiently treated with with their respective drug (5-FU or oxaliplatin) for 0, 6 12 or 24h in 3 independent experiments.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-390 | biostudies-arrayexpress
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Corynebacterium diphtheriae under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol perox...
ORGANISM(S): Corynebacterium diphtheriae 
2017-07-17 | PXD003321 | Pride
Oxicat Corynebacterium diphtheria S-mycothiolation Bacteria Oxidative stress Mycothiol 
ProteomicsMonitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Mycothiol (AcCys-GlcN-Ins, MSH) is the major thiol-redox buffer in Actinomycetes, including Mycobacterium and Corynebacterium species. ). Protein S-mycothiolation controls the activities of several redox enzymes that function in detoxification of ROS and methionine sulfoxides, including the thiol pe...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2017-06-30 | PXD003303 | Pride
Oxicat S-mycothiolation Bacteria Oxidative stress Mycobacterium smegmatis Mycothiol 
ProteomicsIMPRINTS-CETSA, 5-FU in parental and 5-FU-resistant HCT15 cells
Parental and 5-fluorouracil (5-FU)-resistant HCT15 cells were treated with 5-FU or vehicle for 12h and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobar...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026472 | JPOST Repository
TranscriptomicsZebrafish liver transcriptome in response to chronic treatment with environmentally relevant 5-FU
The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite that exerts its anticancer effects through inhibition of DNA synthesis and replication by inhibiting thymidylate synthase, and by incorporation of its metabolites into RNA and DNA. 5-FU is used in most of the currently applied regimens ...
ORGANISM(S): Danio rerio 
2015-04-23 | E-GEOD-63039 | biostudies-arrayexpress
ProteomicsThe sulfur stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics
In this study, we compared the transcriptome signatures under allicin and diallyl tetrasulfane (DAS4) exposure in the Gram-positive bacterium B. subtilis. We further used shotgun proteomics to unravel the overall S-thioallylomes provoked by allicin and DAS4. Allicin and DAS4 caused a similar thiol-s...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2019-12-09 | PXD013607 | Pride
Bacillus subtilis/ allicin/ diallyl polysulfane/ bacillithiol/ s-thioallylation 
ProteomicsMCF7 xenografts with 5-FU in vivo ITDR-CETSA
MCF7 xenograft-bearing mice were treated intravenously for 22h with either vehicle or different 5-FU doses (10, 50, 100, and 150 mg/kg). Each xenograft was cut in similar-sized pieces and assembled into an ITDRCETSA scheme with 2 different heating temperatures (37ºC, 52ºC) and 3 xenograft pieces for...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026470 | JPOST Repository
ProteomicsProtein interactors of 5-FU in MDA-MB-231 cells
This dataset originates from a Proteome Integral Solubility Alteration (PISA) experiment designed to assess how 5-fluorouracil (5-FU) alters protein thermal stability/solubility in MDA-MB-231 cells. Cells were treated with 200 μM 5-FU or DMSO for 2 h, exposed to a temperature gradient, lysed, and so...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD072095 | Pride
5-fluorouracil Mda-mb-231 5-fu Pisa 
TranscriptomicsGene expression patterns induced by 5-Fluorouracil in breast cancer cell lines
We have compared the changes in cell cycle and cell death parameters induced by 2 different concentrations of 5-FU (IC50 and IC80) in the breast adenocarcinoma cell line MCF7. G1/S cell cycle arrest was associated with both concentrations, whereas cell death was mainly induced after IC80 5-FU. These...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-2584 | biostudies-arrayexpress
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