Sort   by:  
 Page size 
ProteomicsPlatynereis head proteome - Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase
A maturation, sex and lunar phase locked Platynereis head proteome was generated by sampling six heads per biological replicate from male and female Platynereis at defined stages of sexual maturation (immature, premature and mature) at two different moon phases; New moon and Free-running Full moon, ...
ORGANISM(S): Platynereis dumerilii 
2019-02-19 | PXD010532 | Pride
Circalunar Sex bias Head Shotgun proteomics Platynereis dumerilii Maturation Labelled proteomics Quantitative proteomics 
ProteomicsKinetic principles of chemical cross-link formation for protein-protein interactions
Proteins play a central role in most biological processes within the cell and deciphering how they interact is key to understand their function. Cross-linking coupled to mass spectrometry is an essential tool for elucidating protein-protein interactions. Despite its importance, we still know surpris...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053500 | Pride
Human s26 proteasome Crosslinking mass spectrometry 
MetabolomicsImpact of in vitro hormone treatments on the bibenzyl production of Radula complanata (Untargeted metabolomics)

Bibenzyls are a specialized metabolite class found throughout the plant kingdom. One of the most prolific producers of bibenzyls are liverworts, specifically plants of the Radula genera. These plants possess an incredible diversity of bibenzyls, prenylated bibenzyls and a few (bis)bibenz...

2024-01-10 | MTBLS3563 | MetaboLights
ProteomicsTranslational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes
Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes. However, how expression of these mRNAs is suppressed to maintain the lo...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-07-18 | PXD062261 | Pride
4et Xenopus laevis Dia Knockdown Label-free quantification 4et-trim 
MetabolomicsLiquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD) and 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone...
2023-11-28 | MTBLS2218 | MetaboLights
ProteomicsIdentification of small molecule activators of the ubiquitin ligase E6AP/UBE3A and Angelman syndrome-derived E6AP/UBE3A variants
Genetic aberrations of the UBE3A gene encoding the E3 ubiquitin ligase E6AP underlie the development of Angelman syndrome (AS). Approximately 10 percent of AS individuals harbor UBE3A genes with point mutations, frequently resulting in the expression of full-length E6AP variants with defective E3 ac...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD020602 | Pride
Ube3a Angelman syndrome Crosslinking coupled to mass spectrometry E6ap Small molecule activator Fluorescence polarization Xl-ms Ubiquitin ligase High-throughput screen 
ProteomicsStructural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation, thereby contributing to carcinogenesis. Moreover, E6 acts ...
ORGANISM(S): Human papillomavirus type 16 Homo sapiens (Human) 
2018-10-23 | PXD010002 | Pride
Xl-ms E6 oncoprotein Ubiquitin E6ap/ube3a P53 Papillomavirus 
TranscriptomicsHistone deacetylase 6 exerts dichotomous effects on the Hedgehog signaling cascade
Murine embryo fibrablosts from stably transfected with Sonic Hedgehog were treated with siRNA and their transcription profiles captured.
ORGANISM(S): Mus_musculus 
2015-01-26 | E-MTAB-2440 | biostudies-arrayexpress
ProteomicsCobalamins function as allosteric activators of an Angelman syndrome-associated UBE3A/E6AP variant
Genetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD048963 | Pride
Lip-ms Small molecule activators Qxl-ms Structural proteomics Ube3a Angelman syndrome 
ProteomicsBoxCar acquisition method enables single shot proteomics at a depth of 10,000 proteins in 100 minutes
Great advances have been made in sensitivity and acquisition speed on the Orbitrap mass analyzer, enabling increasingly deep proteome coverage. However, these advances have been mainly limited to the MS2 level whereas ion beam sampling for the full MS scan remains extremely inefficient. Here we repo...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-10-04 | MSV000084418 | MassIVE
Sort   by:  
 Page size