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MetabolomicsXuezhikang Ameliorating Non-Alcoholic Fatty Liver Disease via the Gut Microbiota-Metabolite-Ferroptosis Axis: A Multi-Omics Study
Objective: This study investigated the therapeutic mechanism by which Xuezhikang (XZK) alleviates non-alcoholic fatty liver disease (NAFLD) in mice, with a specific focus on the interplay between the gut microbiota, metabolic alterations, and hepatic ferroptosis. Methods: An NAFLD mouse model was in...
2026-06-16 | MTBLS14743 | MetaboLights
Proteomicscomparative total proteome analysis for nash biomarker
Nonalcoholic fatty liver disease (NAFLD) is a hepatic condition characterized by excessive fat accumulation, leading to liver fibrosis, cirrhosis, and cancer. Currently, invasive liver biopsy is the only method for identifying and classifying NASH. Mass spectrometry-based proteomics can detect cruci...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053187 | Pride
Full scan mouse liver tribrid 
ProteomicsQuantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation
Fibroblast growth factor 19 (FGF19) is a gut-derived peptide hormone that is produced following activation of Farnesoid X Receptor (FXR). FGF19 is secreted and signals to the liver, where it contributes to the homeostasis of bile acid (BA), lipid and carbohydrate metabolism. FGF19 is a promising the...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-15 | PXD005659 | Pride
Fgf19  growth factor  fxr  liver  proteomics  metabolism  proliferation  tgf 
ProteomicsMulti-omic responses of mouse liver and skeletal muscle to chronic alcohol drinking
The aim of this study was to define and compare the molecular blueprints of chronic alcohol use in the liver and skeletal muscle using an established pre-clinical mouse model.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-11 | PXD064997 | Pride
Multi-omics Mouse Liver Skeletal muscle Chronic alcohol 
ProteomicsMouse liver proteome in Germ-free, Specific pathogen free, and OMM12 colonizes mice
Bile acids (BA) are synthesized in the liver before excretion into the bile. Consequently, to clarify how the gut microbiota increases biliary TCA and TMCA contents, hepatic BA metabolism was investigated by analyzing the liver proteome of GF, OMM12 and SPF mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-30 | PXD060110 | Pride
Mouse Tmt Liver Proteome 
ProteomicsEndogenous cathelicidin protects against Toxoplasma gondii- associated liver damage
Toxoplasmosis, a disease caused by apicomplexan Toxoplasma gondii, is associated with various neuropsychiatric and behavioural conditions. Toxoplasmosis can cause serious complications for those with weakened immune systems and during pregnancy. Cathelicidins, peptides with antimicrobial and immunom...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-19 | PXD062489 | Pride
Cathelicidin  toxoplasma gondii  liver  brain. 
ProteomicsLoss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis
miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor. Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism. Inhibition of miR-33 has been shown to promote cholesterol efflux in macrophages by targeting the cholesterol transport...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD023471 | Pride
Mouse plasma 
ProteomicsNon-poly(A) RNA Interactome Capture (RIC) of mouse brain, kidney and liver
Male mice on a homogenous C57BL6/J genetic background were sacrificed at 11 to 13 weeks of age by cervical dislocation. Brain, kidneys and liver were immediately harvested, flash frozen in liquid nitrogen and stored at -80°C until use. Animal handling was in accordance with guidelines approved by th...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-02 | PXD038076 | Pride
Rna interactome capture. Rbp Ric Eric Rna binding protein Rbpome 
ProteomicsContrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
The conserved phosphoprotein MAF1 is the main known direct repressor of RNA polymerase III (Pol III). MAF1 is phosphorylated and inactivated by the nutrient-sensing TORC1 kinase, making MAF1 a nutrient effector for Pol III transcription. MAF1 has been associated with lipid metabolism in D. melanogas...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD040086 | Pride
Rna polymerase iii Transcription repressor Maf1 Hepatocyte Mouse Metabolic regulation 
ProteomicsCholangiocyte organoid culture in hydrogels from decellularized liver tissue
Culture of human cholangiocyte organoids in hydrogels derived from healthy liver extracellular matrix (LECM) extracts prepared from decellularized human livers are evaluated in an effort to establish a platform for production of cholangiocyte organoids for clinical regenerative applications. Human ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD028417 | Pride
Human Regeneration Hydrogel Liver Cholangiocyte Organoid 
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