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ProteomicsProteogenomic analysis in hibernating mammal suggests contribution of skeletal muscle physiology to hibernation phenotype
Mammalian hibernation is a strategy employed by many species to survive fluctuations in resource availability and environmental conditions. Hibernating mammals endure conditions of dramatically depressed heart rate, body temperature, and oxygen consumption; yet show no typical pathological response...
ORGANISM(S): Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) 
2018-07-11 | PXD003188 | Pride
Amp –deaminsase 1 Proteomics Itraq Skeletal muscle Fibromodulin Galaxy-p Hibernation 
ProteomicsPrediction of Mortality In Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) continues to have a high mortality. The objective of this study is to understand the differences in disease biology between survivors and non-survivors by characterizing BALF protein expression profiles in individual ARDS subjects.
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002672 | Pride
Bal Galaxyp Itraq Ards Biomarkers 2dlc-ms/ms 
ProteomicsHigh-throughput identification of FLT3 wild-type and mutant kinase substrate preferences and application to design of sensitive in vitro kinase assay substrates
Abnormalities in the FLT3 signaling pathway play an integral role in AML disease relapse and drug resistance. Developing new and specific FLT3 tyrosine kinase inhibitors for use in combination to induction therapy is an important step to reduce disease relapse and achieve clinical remission. To deve...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD011478 | Pride
Kinase assay linked with phosphoproteomics Flt3 Acute myeloid leukemia Mass spectrometry Phosphoproteomics 
ProteomicsMetaproteomic analysis using the Galaxy framework
Metaproteomics characterizes proteins expressed by microorganism communities (microbiome) present in environmental samples or a host organism (e.g. human), revealing insights into the molecular functions conferred by these communities. Compared to conventional proteomics, metaproteomics presents un...
ORGANISM(S): Homo sapiens (Human) 
2015-07-02 | PXD001655 | Pride
Metaproteomics   workflows. 
ProteomicsProteome Profiling in Lung Injury Following Hematopoietic Stem Cell Transplantation
The goal of this study was to apply protein expression profiling tools in cases with lung injury following HSCT or cellular therapy infusion to identify the proteins and biological processes that differentiate IPS from infectious lung injury in HSCT recipients. We performed comprehensive label-base...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002437 | Pride
Balf Hsct Itraq Orbitrap 2dlc-ms/ms 
ProteomicsTwo cancer-promoting stromal gene expression programs depend on lung function
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer, suggesting that COPD stroma favors cancer initiation. Therefore, we used proteomics and polysome-profiling to identify gene expression programs that distinguish stroma of patients harboring lung cancer from t...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD007743 | Pride
Human Translatomics Copd Lung tissue Transcriptomics Proteomics Emphysema Lung cancer 
ProteomicsProtein Pathways in Controls vs Progressive and NonProgressive Pulmonary Sarcoidosis
Investigate the differences between Sarcoidosis and Controls as well as between progressive and nonprogressive pulmonary sarcoidosis using 2D LC-MS/MS proteomics instrumentation and bronchoalveolar lavage samples. MaxQuant was used for database searches label free quantitation followed by Ingenuity ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD016637 | Pride
Ms/ms Pathways Proteomics Balf Maxquant Sarcoidosis Biomarkers 
ProteomicsMatched Lung Tumor And Emphysematous Matrix Proteomics, Transcriptomics, and Translatomics
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer suggesting that the COPD stroma contains factors supporting tumorigenesis. Since cancer initiation is complex we used a multi-omic approach to identify gene expression patterns that distinguish COPD stroma...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD007919 | Pride
Translatomics Copd Lung cancer Data integration Transcriptomics Rna Jive Proteomics Emphysema 
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