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ProteomicsProteomic and phosphoproteomic profiling of ARPE19 cells and Abca4-/-Rdh8-/- mice exposed to stress
To obtain an unbiased, thorough understanding of the biological pathways implicated in atRAL-induced cytotoxicity and PDE inhibitor-mediated cytoprotection, we performed a mass spectrometry-based quantitative proteomic analysis of ARPE19 cells, using stable-isotope labeling of amino acids in cell cu...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-26 | PXD035841 | Pride
Phosphodiesterases Vision Cell culture Stress Neuroprotection Neurodegeneration Retina Lc-ms/ms 
ProteomicsPolyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Restoration of Vision in Aging
The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), which are primarily localized in cell membranes, where they govern membrane biophysical properties such as diffusion, permeability, domain formation, and curvature generation. During aging, alterations in lipid metabolism lead t...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-02 | PXD066430 | Pride
Vlc-pufa Lipid supplementation Pufa Amd Elovl2 Aging 
ProteomicsScalable purification enables high-quality virus-like particles for therapeutic translation
Emerging molecular therapies introduce enzymatic activity into cells by delivering genes, transcripts, or proteins. Owing to their robust cell-entry capacity, virus-like particles (VLPs) represent a technology of choice in genome editing, where low doses of heterologous proteins and nucleic acids ar...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD070195 | Pride
Prime editing Protein delivery Crispr/cas Nanotechnology Cas9 Chromatography Virus-like particles Base editing Vesicles Ribonuclear protein (rnp) 
ProteomicsRestoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in Adiponectin receptor 1 (AdipoR1) deficient mice
Mutations in the adiponectin receptor 1 gene (AdipoR1) lead to retinitis pigmentosa and are associated with age-related macular degeneration (AMD). This study explores the effects of AdipoR1 gene deficiency in mice, revealing a striking decline in ω3 polyunsaturated fatty acids (PUFA), an increase i...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-23 | PXD050916 | Pride
Proteomics Lipidomics Retinal pigment epithelium (rpe) Retina Polyunsaturated fatty acids (pufas) 
ProteomicsLow Dose Radiation Induces New Protein Synthesis that Promotes Cancer Radiotherapy Resistance
Radiotherapy (RT) is a cornerstone of cancer treatment; however, its efficacy is frequently hampered by its adverse effects on normal tissues. By studying the effects of high-dose radiotherapy (HDRT) and low-dose radiotherapy (LDRT), we found that cancer cells adapt distinct responses to these doses...
ORGANISM(S): Homo Sapiens 
2026-02-26 | PXD074928 |
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