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In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs) following membrane depolarization regulates crucial Ca2+-dependent processes including duration and amplitude of the action potentials and excitation-contraction coupling. LTCCs are heteromultimeric proteins compose...
ORGANISM(S): Rattus rattus (Black rat) 
2021-12-14 | PXD021375 | Pride
We have identified and characterized two lysine (K) deacetylase inhibitors (DACi), CM-444 and CM-1758. These inhibitors demonstrate the ability to promote myeloid differentiation in all acute myeloid leukemia (AML) subtypes at low, non-cytotoxic doses, setting them apart from other commercially avai...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD050623 | Pride
Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend thedisease’s pathogenesis iscrucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles s...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD038003 | Pride
The physiological niche of bone marrow is hypoxic. However, the artificial growth of bone marrow derived-mesenchymal stromal cells (MSC)s very often occurs in normoxia which may impact the protein expression with immunomodulatory properties. Thus, cell viability and respiration were assessed as well...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD027718 | Pride
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