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ProteomicsProteomic analysis of RacK1 immunoprecipitates from Torin1-treated wild-type HeLa cells
This study investigates protein complexes associated with RacK1 under conditions of mTOR inhibition. Wild-type HeLa cells were treated with the mTOR inhibitor Torin1, followed by immunoprecipitation using a RacK1-specific antibody to enrich RacK1-associated protein complexes. The immunoprecipitates ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-21 | PXD073592 | Pride
Torin1 Immunoprecipitation Rack1 Lc–ms/ms 
ProteomicsProteomic analysis of nascent proteins in proximity to DFCP1 using SILAC labeling and APEX2-mediated biotin-streptavidin affinity purification.
This study employs a spatial proteomics approach combining APEX2 proximity labeling with SILAC (Stable Isotope Labeling by Amino acids in Cell culture) to map the nascent proteome in the vicinity of DFCP1.
ORGANISM(S): Homo sapiens (Human) 
2026-02-21 | PXD073558 | Pride
Proximity labeling Autophagy Apex2 Silac Nascent proteins Dfcp1 
ProteomicsA complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy - PART 3
Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while ALS-linked mutations in other proteins impede elimination of stress granules. Repeat expansions in C9ORF72, the major cause of ALS, reduce C9ORF72 levels but how t...
ORGANISM(S): Homo sapiens (Human) 
2018-07-25 | PXD009760 | Pride
Lc-msms Prmt5 Arginine dimethylation Fus Als Oxidate stress 
ProteomicsA complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy - PART 1
Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while ALS-linked mutations in other proteins impede elimination of stress granules. Repeat expansions in C9ORF72, the major cause of ALS, reduce C9ORF72 levels but how t...
ORGANISM(S): Homo sapiens (Human) 
2018-07-26 | PXD009759 | Pride
Lc-msms Oxidative stress Als C9orf72 
ProteomicsA complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy - PART 2
Mutations in proteins like FUS which cause Amyotrophic Lateral Sclerosis (ALS) result in the aberrant formation of stress granules while ALS-linked mutations in other proteins impede elimination of stress granules. Repeat expansions in C9ORF72, the major cause of ALS, reduce C9ORF72 levels but how t...
ORGANISM(S): Homo sapiens (Human) 
2018-07-26 | PXD009741 | Pride
Lc-msms Oxidative stress Als Sqstm1 
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