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MetabolomicsTissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1-mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. However, large databases with tissue metabolites that are modulated by IDH1 mutation remain an area of development. Here, we present a...
2022-09-07 | MTBLS3873 | MetaboLights
UnknownNon-orthosteric inhibition of enolase 1 impedes growth of triple-negative breast cancer.
Not available
S-EPMC12711674 | biostudies-literature
ProteomicsYB-1 inhibition suppresses osteosarcoma growth and reverses tumor immunosuppression
U2OS, and SaOS cells were treated with DMSO (vehicle control) or SU056 (24h). Quantitative proteomics analysis was performed on cell lysates.
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD074439 | Pride
Yb-1 Osteosarcoma Cell lines Treatment 
ProteomicsNon-allosteric Inhibition of Enolase 1 Impedes Growth of Triple-Negative Breast Cancer
1. Cellular Thermal Shift Assay (CETSA): MDA-MB-231 cells were treated for 6h with DMSO or SU212 and incubated at different temperatures and protein differences in the soluble fractions were determined. 2. Quantitative Proteomics: MDA-MB-231, MDA-MB-468, and BT549 cells were treated with DMSO (vehi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-10 | PXD061466 | Pride
Non-allosteric inhibition Eno1 Aza-podophyllotoxin derivative Enolase Triple-negative breast cancer 
UnknownMICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation
Not available
S-SCDT-EMBOJ-2019-104105 | biostudies-other
UnknownGenomewide Association Study of Severe Covid-19 with Respiratory Failure.
Not available
S-EPMC7315890 | biostudies-literature
TranscriptomicsEvaluation of methods for modeling transcription factor sequence specificity
Genomic analyses often involve scanning for potential transcription-factor (TF) binding sites using models of the sequence specificity of DNA binding proteins. Many approaches have been developed to model and learn a protein’s binding specificity by representing sequence motifs, including the gaps a...
ORGANISM(S): synthetic construct 
2012-12-13 | E-GEOD-42864 | biostudies-arrayexpress
UnknownDetailed stratified GWAS analysis for severe COVID-19 in four European populations.
Not available
S-EPMC9703941 | biostudies-literature
UnknownAssociation between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE).
Not available
S-EPMC8815825 | biostudies-literature
UnknownPeri-interventional outcome study in the elderly in Europe: A 30-day prospective cohort study.
Not available
S-EPMC8815832 | biostudies-literature
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