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ProteomicsDifferential proteomes in the vitreous of mice with a chronic hypoxic response in photoreceptors
Reduced oxygenation of photoreceptors and the RPE in the ageing eye may be a risk factor for the development of both neovascular and dry AMD. Chronic activation of the molecular response to hypoxia in RPE or photoreceptors leads to retinal degeneration that depends on hypoxia inducible transcription...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-12 | PXD008911 | Pride
Retinal degeneration Vitreous Cones Rods Hypoxic response Amd Shot-gun proteomics 
ProteomicsThe Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease
In contrast to neovascular age-related macular degeneration (nAMD), no treatment option exists for dry AMD. The identification of specific biomarkers is required to facilitate diagnosis and therapy of dry AMD. We thus measured the proteome of 34 vitreous humor samples (dry AMD: n = 6, nAMD: n = 10, ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-23 | PXD008354 | Pride
Pdr Proliferative diabetic retinopathy Dry amd Age-related macular degeneration Neovascular amd Epiretinal membrane Vitreous proteome Human Biomarker Vitreous humor Namd Erm 
ProteomicsChronic hypoxic response in rod photoreceptors
In this study, we address the underlying cause of photoreceptor degeneration by focusing on alterations in energy metabolism during chronic HIF activation. Using layer-specific proteomics, we analyzed proteome alterations in photoreceptor segments and cell bodies upon chronic HIF activation.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-29 | PXD034057 | Pride
Mouse Hypoxia Rod photoreceptor 
UnknownA diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression.
Not available
S-EPMC3283438 | biostudies-literature
TranscriptomicsTranscription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection
Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data sugges...
ORGANISM(S): Mus musculus 
2009-01-17 | E-GEOD-14366 | biostudies-arrayexpress
TranscriptomicsExpression data from pulmonary metastases of clear-cell renal cell carcinoma
The understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis, like varying dormancy periods of Mets originating from the same primary tumor entity or the differing number of Mets in patients with the same primary tumor, are largely unkno...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-14378 | biostudies-arrayexpress
UnknownCatalytic Oxygenation of Hydrocarbons by Mono-μ-oxo Dicopper(II) Species Resulting from O-O Cleavage of Tetranuclear CuI /CuII Peroxo Complexes.
Not available
S-EPMC8251984 | biostudies-literature
UnknownDeterminants of delayed childhood cancer care in low- and middle-income countries: A systematic review.
Not available
S-EPMC10966942 | biostudies-literature
UnknownFactors contributing to delayed childhood cancer care in low- and middle-income countries: A systematic review protocol.
Not available
S-EPMC11456978 | biostudies-literature
TranscriptomicsThe bromodomain protein BRD4 regulates splicing during heat shock
During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress
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