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ProteomicsSERPA: Autoantibody profiling in POAG
Glaucoma is the leading cause of irreversible blindness worldwide. An early diagnosis of the disease is crucial for treatment success. Mechanisms behind glaucoma pathogenesis are not completely understood, but disease related alterations in the serological autoantibody profile indicate an immunologi...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2019-02-21 | PXD011752 | Pride
Autoantibodies  serpa  immunoproteomics  glaucoma  poag 
ProteomicsLectin-based affinity enrichment and characterization of N-glycoproteins from the human tear film by mass spectrometry
Glycosylation of proteins is one of the most common post-translational modification (PTM) and plays important regulatory functions in diverse biological processes such as protein stability or cell signaling. Accordingly, glycoproteins are also a consistent part of the human tear film proteome mainta...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2023-01-25 | PXD038280 | Pride
N-glycoproteins Mass spectrometry Pngase f Tear film Multi-lectin column 
ProteomicsDNA mismatch repair activity of MutLalpha is regulated by CK2-dependent phosphorylation of MLH1
Mass spectrometry based PTM phosphorylation analysis to study regulation mechanism of MUTL alpha, a heterodimer consisting of MLH1 and PMS2 and a key player in DNA mismatch repair (MMR). It could be demonstrated that phosphorylation of MLH1 by Casein Kinase II (CK2) at amino acid position 477 can sw...
ORGANISM(S): Homo sapiens (Human) 
2018-08-29 | PXD009026 | Pride
Hek293t cells Phosphorylation Immunoprecipitation Mutl alpha Lc-ms/ms 
ProteomicsGlaucoma-Associated CDR1 Peptide Promotes RGC Survival in Retinal Explants through Molecular Interaction with Acidic Leucine Rich Nuclear Phosphoprotein 32A (ANP32A)
Glaucoma is a complex, multifactorial optic neuropathy mainly characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, resulting in a decline of visual function. The pathogenic molecular mechanism of glaucoma is still not well understood, and therapeutic strategies spe...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2023-08-01 | PXD038373 | Pride
Glaucoma Neuroprotection Mass spectrometry Proteomics Anp32a 
ProteomicsA monoclonal anti-HMGB1 antibody attenuates neurodegeneration in an experimental animal model of glaucoma
Neuroinflammation is a crucial process for the loss of retinal ganglion cells (RGC), a major characteristic of glaucoma. High expression of high mobility group box protein 1 (HMGB1) plays a detrimental role in inflammatory processes and is elevated in the retinas of glaucoma patients. Therefore, thi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD031987 | Pride
Glaucoma Discovery proteomics Neuroprotection Microarray Antibodies Neurodegeneration Animal model 
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081757 | MassIVE
ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
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