Sort   by:  
 Page size 
ProteomicsEnglerin A rewires phosphosignaling via HSP27 hyperphosphorylation to induce cytotoxicity in renal cancer cells
Englerin A (EA) is a small molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell cycle arrest and/or insulin signaling pathways. However, its specific biological mode of action or targets in renal cancer rem...
ORGANISM(S): Homo sapiens (Human) 
2022-07-25 | PXD034333 | Pride
Hsp27 Anti-cancer drug Phosphoproteomics Renal cancer Englerin a 
ProteomicsEPLIN-Beta is a novel substrate of ornithine decarboxylase antizyme 1, mediating cellular migration
Polyamines promote cellular proliferation, and their levels are controlled by ornithine decarboxylase antizyme 1 (Az1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis. Az1-mediated degradation of...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD039865 | Pride
Ubiquitin-independent degradation Antizyme Cell migration Eplin/lima1 
ProteomicsComprehensive proteomic characterization reveals subclass-specific molecular aberrations within triple-negative breast cancer
Triple-negative breast cancer (TNBC) is regarded as the most aggressive subtype of breast cancer lacking targeted therapies. This is attributed to its high heterogeneity that complicates elucidation of its molecular aberrations. Here, we report identification of specific proteome expression profiles...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD017025 | Pride
Triple-negative Tnbc Proteomics Mass spectrometry Protease Breast cancer Kinase 
ProteomicsPhosphoproteome profiling unravels rewiring of chromatin organization factors in host cells upon HBV infection
Hepatitis B virus (HBV) infection leads tdevelopment of fatal liver complications. Due to a lack of effective measure to cure HBV infection, complete eradication of HBV is difficult. Thus, novel HBV therapeutic strategies are needed. Host proteins involved in the HBV infection processes are known to...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD015393 | Pride
Hbv host response Mass spectrometry Hepatitis b virus Phosphoproteome Chromatin remodelling 
ProteomicsGreatwall kinase regulates SAC by controlling phosphorylation and activity of MPS1
The Greatwall/Mastl kinase is an essential gene, which regulates the phosphatase activity that counteracts the phosphorylation of Cdk1 substrates. Although Mastl-/- MEFs can enter mitosis, they are unable to complete mitosis due to chromosome segregation defects. Here, we show that Mastl is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004882 | Pride
Greatwall kinase/mastl/cyclin-dependent kinase/knockout mice/cdk1/mps1/sac 
ProteomicsPhosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet
Despite wide efforts in the last decade, signaling aberrations associated with obesity remain enigmatic. Here, we carried out phosphoproteomic analysis of mouse white adipose tissues (WAT) upon low-fat diet (LFD) and high-fat diet (HFD) to dissect underlying molecular mechanisms of obesity. Of the 7...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-20 | PXD002927 | Pride
Diet Mouse phosphoproteome 
ProteomicsProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions.
Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is demonstrably enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. In U2OS cells expressing PAK4-B...
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024464 | Pride
Lzts2 Pak4 Cdc42 Bioid Epithelial cells Protein kinase Cell junctions 
ProteomicsPhosphoproteomics reveals network rewiring to a pro-adhesion state in Annexin-1-deficient mammary epithelial cells
Background Annexin-1 (ANXA1) plays pivotal roles in regulating various physiological processes including inflammation, proliferation and apoptosis, and deregulations of ANXA1 functions have been associated with tumorigenesis and metastasis events in several cancers. Though ANXA1 levels correlate wit...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-13 | PXD007051 | Pride
Breast cancer Proteomics Annexin-1 Adhesion Phosphoproteomics Network analysis Mammary epithelial cells 
ProteomicsTracking genome-editing and associated molecular perturbations by SWATH mass spectrometry
Advances in gene editing now allow reverse genetics to be applied to a broad range of biological systems. Ultimately, any modification to coding sequences requires confirmation at the protein level, although immunoblotting is often hampered by antibody quality or availability especially in non-mamma...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Bicyclus anynana Mus musculus (Mouse) 
2019-10-24 | PXD013176 | Pride
Crispr Swath Gene editing 
ProteomicsA multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis
Targeted proteomic mass spectrometry is emerging as a salient clinical diagnostic tool to track protein biomarkers. Yet, its strong analytical properties have not been exploited in the diagnosis and typing of flavivirus. Here, we report the development of a highly sensitive and specific single-shot ...
ORGANISM(S): Flavivirus 
2019-03-25 | PXD006922 | Pride
Flavivirus. Targeted proteomics Dengue 
Sort   by:  
 Page size