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ProteomicsProteomic alterations in early stage cervical cancer
Cervical cancer is characterized by a well-defined pre-malignant phase, cervical intraepithelial neoplasia (CIN). Identification of high grade CIN lesions by population-based screening programs and their subsequent treatment has led to a significant reduction of the incidence and mortality of cervic...
ORGANISM(S): Homo sapiens (Human) 
2018-05-03 | PXD008723 | Pride
Cervical cancer Proteomics Prm Lcm Biomarker 
ProteomicsUpregulation of filaggrin 2 in scleritis using tissue mass spectrometry
Scleritis is a severe inflammatory ocular disorder with unknown pathogenesis. Using a mass spectrometry approach, we investigated healthy sclera and sclera affected by non-infectious scleritis for differentially expressed proteins. Therefore, we collected scleral samples of enucleated eyes due to se...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038727 | Pride
Tissue Scleritis Nano-lcms Dda 
ProteomicsQuantification of calcyclin and heat shock protein 90 in sera from women with and without preeclampsia by mass spectrometry
Maternal serum levels of calcyclin and heat shock protein 90 were compared throughout pregnancy from the first trimester till term among women with preeclampsia (PE) and age-matched normotensive pregnant controls (C). Serum samples from two different studies, a nested case-control study embedded in ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD009025 | Pride
Hsp90 S100a6 Prm Serum Preeclampsia Placenta 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha, part 1
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD006618 | Pride
Srm Hsp90 Prm Scx Serum Elisa 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD006569 | Pride
Srm Hsp90 Prm Scx Serum Elisa 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD006615 | Pride
Srm Hsp90 Prm Scx Serum Shotgun Elisa Dda 
ProteomicsComparison of targeted mass spectrometry techniques with an immunoassay: a case study for HSP90 alpha, part 2
We developed 2D-LC-MS/MS-based SRM and PRM assays to measure HSP90 alpha in serum and compared the results to a commercially available immunoassay (ELISA). Serum samples were trypsin-digested and fractionated by SCX chromatography prior to SRM and PRM measurements. PRM data obtained by high-resoluti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD007601 | Pride
Srm Hsp90 Prm Scx Serum Elisa 
ProteomicsCerebrospinal fluid of preeclamptic and normotensive pregnant women compared to non-pregnant women analyzed with mass spectrometry.
The objective of the present study was to study whether pregnancy-related proteins are associated with preeclampsia.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD017862 | Pride
Blood-brain barrier  cerebrospinal fluid  preeclampsia  pregnancy  calcium-binding proteins 
ProteomicsQuantitative proteomic analysis of MCM3 in ThinPrep samples of patients with cervical preinvasive cancer
Triage methods for cervical cancer detection show moderate accuracy and present considerable false-negative and false-positive result rates. A complementary diagnostic parameter could help improve the accuracy of identifying patients who need treatment. A pilot study was performed using a targeted p...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042919 | Pride
Human Mcm3 Cervical cancer Dda 
ProteomicsQuantitative proteomic analysis of MCM3 in ThinPrep samples of patients with cervical preinvasive cancer
Triage methods for cervical cancer detection show moderate accuracy and present considerable false-negative and false-positive result rates. A complementary diagnostic parameter could help improve the accuracy of identifying patients who need treatment. A pilot study was performed using a targeted p...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042918 | Pride
Human Prm Mcm3 Cervical cancer 
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