Sort   by:  
 Page size 
ProteomicsARL6IP1 is an interacting partner of the ER-phagy receptor FAM134B
ER-resident membrane-shaping proteins with central reticulon homology domains (RHDs) have been associated with neurodegenerative disorders such as ARL6IP1 and FAM134B.Mutations in ARL6IP1 cause SPG61, a neurodegenerative disorder characterized by progressive leg spasticity (hereditary spastic parapl...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032718 | Pride
Ha fam134b Arl6ip1 
ProteomicsFAM134B homodimer ubiquitination
FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032740 | Pride
Venus fam134b and fam134c dimers 
ProteomicsThe ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection
Macroautophagy/autophagy is a key catabolic-recycling pathway that can selectively target damaged organelles or invading pathogens for degradation. The selective autophagic degradation of the endoplasmic reticulum (hereafter referred to as ER-phagy) is a homeostatic mechanism, controlling ER size, t...
ORGANISM(S): Homo sapiens (Human) Salmonella enterica subsp. enterica 
2025-05-07 | PXD061148 | Pride
Ap-ms sopf fam134b 
ProteomicsUbiquitination promotes FAM134B-mediated ER-phagy
FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032721 | Pride
Gfp-fam134b Ubiquitin 
ProteomicsE3 ligase regulates FAM134B ubiquitination
FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032750 | Pride
Venus amfr fam134b basal torin1 
ProteomicsFAM134B oligomer ubiquitination and ER-phagy
FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032741 | Pride
Venus fam134b ubiquitinated sites 
ProteomicsBinding partners of FAM134B WT and 17KR oligomers
FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032743 | Pride
Venus fam134b wt and 17 kr 
ProteomicsARL6IP1 and FAM134B forms a complex
ER-resident membrane-shaping proteins with central reticulon homology domains (RHDs) have been associated with neurodegenerative disorders such as ARL6IP1 and FAM134B.Mutations in ARL6IP1 cause SPG61, a neurodegenerative disorder characterized by progressive leg spasticity (hereditary spastic parapl...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD032720 | Pride
Venus arl6ip1 and heterodimer fam134b 
ProteomicsIn vivo FAM134B ubiquitination in AMFR KD cells
FAM134B is a reticulon-homology domain (RHD)-containing protein that participates in membrane-shaping of the endoplasmic reticulum (ER)8 13. It also functions as a mammalian ER-phagy receptor, mediating the fragmentation and selective degradation of ER sheets in multiple cell types8. However, little...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD039187 | Pride
Human Amfr Co-ip Fam134b 
ProteomicsThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and is critical to maintaining cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a role during stress-induced ER-phagy. How...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD043003 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Ubiquitination. Stress response Fam134b Fam134c Endoplasmic reticulum Mtor 
Sort   by:  
 Page size