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ProteomicsA covalent fragment screen identifies ferroptosis induced by GPX4 inhibition as a vulnerability of senescent cells
Senescent cells drive ageing and age-related pathologies, including cancer. Consequently, senolytics, drugs that selectively kill senescent cells, have a broad therapeutic appeal. Here, we report a senolytic screen of a library of 10,480 covalent fragments. Amongst 44 identified hits, we found a ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068572 | Pride
Gpx4 Rsl3 Cancer Senescence Covalent fragments Ferroptosis Senolytics One-two punch Covalent inhibitors Chloroacetamides 
ProteomicsLipid metabolism drives osimertinib resistance in non-small cell lung cancer
Non-small-cell lung cancer (NSCLC) accounts for more than 80 % of lung cancer cases. Epidermal growth factor receptor mutations (EGFRm) occur in 15 % and 40 % of NSCLC in Western and Asian populations, respectively. Current treatment for advanced NSCLC targets EGFRm with tyrosine kinase inhibitors (...
ORGANISM(S): Homo sapiens (Human) 
2026-03-03 | PXD071008 | Pride
Nonsmall-cell lung cancer  lipidomics  glycosphingolipid  ceramide  sphingolipid Drug resistance  multi-omics  glucosylceramidase 
ModelsTFInfer: a tool for probabilistic inference of transcription factor activities
TFInfer: a tool for probabilistic inference of transcription factor activities
2013-01-14 | 102 | FAIRDOMHub
UnknownAn Engineered Prussian Blue Nanoparticles-based Nanoimmunotherapy Elicits Robust and Persistent Immunological Memory in a TH-MYCN Neuroblastoma Model.
Not available
S-EPMC8382205 | biostudies-literature
UnknownInterstitial Photothermal Therapy Generates Durable Treatment Responses in Neuroblastoma.
Not available
S-EPMC9588730 | biostudies-literature
ProteomicsHypomorphic mutations in PLAA cause an infantile neurodevelopmental syndrome by disrupting synaptic protein turnover through multivesicular body dysfunction
During endosomal trafficking, the ubiquitin-status of membrane-bound protein cargo determines whether it is recycling to the surface or trafficked through intermediate multivesicular bodies (MVBs) for lysosomal degradation. Neurons, particularly their synapses, are extremely sensitive to perturbatio...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD003140 | Pride
Mouse cerebelluym 
ProteomicsCentriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1. Pcm1-/- mice display partially expressive perinatal lethality with survivors exhibiting hydrocephalus, oligospermia...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD031920 | Pride
Mtecs Cilia 
ProteomicsDistinct spectrum of ciliopathic diseases results from de novoTUBB4B variants through differential effects on organelle-specific microtubules
Microtubules are ancient and highly conserved polymers composed of alpha and beta tubulin heterodimers. Their dynamic remodelling drives diverse cellular processes from organelle trafficking and chromosome segregation to templating more stable structures like those of centrioles and ciliary axonemes...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-30 | PXD036304 | Pride
Tubulin Cilia 
UnknownBCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage
Not available
S-SCDT-EMBOJ-2020-105561 | biostudies-other
UnknownEarly discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report.
Not available
S-EPMC5055162 | biostudies-literature
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