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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
ProteomicsCo-IP/MS for determining interacting partners of TSG-6 in human pHSCs
Interacting partners of TSG-6 were analyzed by coimmunoprecipitation (co-IP) coupled with liquid chromatography tandem mass spectrometry (LC–MS/MS)
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD047449 | Pride
Human Tsg-6 Primary hepatic stellate cells Co-ip/ms 
ProteomicsMouse hippocampus LC/MS with TMT labeling
Transgenic mouse models have been widely used to investigate the pathology of Alzheimer’s disease (AD). To elucidate underlying mechanisms of AD pathogenesis by amyloid beta (Aβ) and tau, we have generated a novel animal model of AD; ADLP - APT mice (Alzheimer’s Disease-Like Pathology) – carrying mu...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-25 | PXD006214 | Pride
Mouse Tmt Hippocampus Lc/ms 
ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to batch variation, high cost, and...
ORGANISM(S): Sus scrofa (Pig) Mus musculus (Mouse) 
2022-02-10 | PXD023694 | Pride
Organoid Matrigel Lc-ms/ms 
ProteomicsTranscriptome and proteome analysis of the human corneal endothelium and aqueous humor reveal endothelial cell dysfunction markers
Background: The underlying mechanism as well as diagnostic molecular biomarkers for corneal endothelial cell dysfunction (CECD) remain elusive. This study aimed to elucidate molecular mechanism of CECD via proteomic and transcriptomic approaches and identify novel biomarkers in aqueous humor (AH) di...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD023772 | Pride
Proteomics Aqueous humor Corneal endothelial cell dysfunction Transcriptomics Biomarker Bullous keratopathy 
ProteomicsDIA-based Proteomic analysis of human islets with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD074587 | Pride
Human Islets Dia Perk inhibitor 
ProteomicsProteomic analysis on human islet with treatment of a PERK inhibitor
Partial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. We conducted this study to elucida...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD066613 | Pride
Tmt Perk inhibitor Islet 
ProteomicsIn-depth proteome analysis of brain tissue from Ewsr1 gene knock-out mice
Ewing’s Sacroma (EWS) is a carcinogenic bone tumor which is predominantly occurred in young adults. EWS RNA binding protein 1 (Ewsr1) protein is well-known as a multifunctional protein and its epigenetic signatures contribute to the pathogenesis of various human disease such as neurodegenerative dis...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD026994 | Pride
Ewsr1 Mice Tandem mass tag 
ProteomicsDeep proteome profiling of hippocampus in 5xFAD mouse model
Alzheimer's disease (AD) is the most common neurodegenerative disease and characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. Although extensive research was performed for Alzheimer's disease (AD) is the most common neurodegenerative disease an...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012238 | Pride
Hippocampus 5xfad Label-free quantification 
Proteomicsquantitative proteomic analysis of proteasome in response to MG132
The ubiquitin-proteasome system and autophagy are two major intracellular proteolytic pathways and both remove misfolded and proteotoxic proteins from eukaryotic cells. This study describes the detailed informations about the change in composition and interactome of proteasomes after prolonged MG132...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019193 | Pride
Proteasome Interactome Mg132 
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