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ProteomicsFoetal and adult HSPCs - Comprehensive Proteomic Characterization of Ontogenic Changes in Hematopoietic Stem and Progenitor Cells
Haematopoietic stem and progenitor cells (HSPCs) in the foetus and adult possess distinct molecular landscapes that regulate cell fate and change their susceptibility to initiation and progression of haematopoietic malignancies. The proteomic programs that govern these differences remain elusive. In...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-12 | PXD006876 | Pride
Haematopoiesis Mouse Adult bone marrow Foetal liver 
ProteomicsEGR1 regulation in human bone marrow stromal cells
Human bone marrow stromal cells (BMSCs) are key elements of the hematopoietic environment and they play a central role in bone and bone marrow physiology. However, how key BMSC functions are regulated is largely unknown. We analyzed the role of the immediate early response transcription factor EGR1 ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-27 | PXD011767 | Pride
Human Bone marrow Stromal cells 
ProteomicsActivation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors
DNA methylation is an important epigenetic modification that is thought to contribute to the maintenance of genomic integrity in somatic cells, in part through the silencing of transposable elements (TEs). In this study we used CRISPR/Cas9 mediated gene editing to disrupt DNMT1, the key maintenance ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD008648 | Pride
Human Lc-msms Dnmt1 
ProteomicsKMT2A-rearranged leukemia proteomics
Activating mutations in kinase/PI3K/RAS signaling pathways are common in acute leukemia with KMT2A rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remain unclear. Using a retroviral acute myeloid leukemia model, we demonstrate that NRASG12D, FLT3ITD, and FLT...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-02 | PXD008213 | Pride
Leukemia Mouse Tmt 
ProteomicsTandem mass tag (TMT) quantitative proteomics of human acute myeloid leukaemia (AML)
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely uncertain. Here, by performing high-resolution proteomic an...
ORGANISM(S): Homo sapiens (Human) 
2020-02-21 | PXD008307 | Pride
Human Lc-msms Tmt Aml Leukemic stem cells 
ProteomicsHematopoietic Stem Cell (HSC) and Multipotent Progenitor (MPP1) quantitative proteomics
During adult bone marrow hematopoiesis, extremely rare and dormant hematopoietic stem cells (HSCs) harbor the highest self-renewal activity within all blood cells. They give rise to active HSCs, which generate multipotent progenitors (MPPs) which differentiate into lineage-committed progenitors and ...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-21 | PXD000572 | Pride
Mouse Hsc Hematopoiesis 
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
ProteomicsQuantitative proteome analysis to map the targets of small molecule UM171
Earlier we identified the protein degradation properties of small molecule UM171 (Subramaniam et al., 2020, Blood). Here we employed quantitative proteomics approach to map the global targets of UM171. Our study revealed multiple targets including the members of CoREST complex such as RCOR1 and LSD1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD037999 | Pride
Um171 Protein degradation. Corest 
ProteomicsRegulatory T-cell LC-MSMS - Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus
In this study, the proteomes of regulatory T cells (Treg) and conventional T cells (Tconv) were compared in a quantitative proteomics approach.
ORGANISM(S): Mus musculus (Mouse) 
2015-09-01 | PXD000794 | Pride
Lc-msms Treg Mouse 
ProteomicsDefective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia
Despite the advanced understanding of disease mechanisms, the current therapeutic regimens fail to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell (LSC) function and leukemia propagation. We apply ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-08 | PXD038318 | Pride
Aml Ribosome Lsc 
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