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TranscriptomicsT cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.
It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell line...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-MTAB-4889 | biostudies-arrayexpress
ProteomicsM.musculus - T cell, SC (Hukelmannetal,natimmunol2016)
abundance based on Spectral counting, Interaction consistency score: 16.2, Coverage: 30
ORGANISM(S): 10090 
2016-00-00 | 190918057 | PAXDB
TranscriptomicsGenome-wide analysis of early transcriptional events induced by cytokine IL-4 in human cord blood CD4+ T cells
The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells. Total RNA obtained from activated and IL-4 & anti-IL-12 treated cord blood CD4+ T cells, 0.5, 1, 2, 4, 6, 12, 24, 48, and 72 hours after initiation of the cultu...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17974 | biostudies-arrayexpress
ProteomicsThe PI3Kδ interactome in naïve and activated mouse CD4+ T cells
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit associated with a p85α or p85β regulatory subunit and is preferentially engag...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-08 | PXD022607 | Pride
Ap-ms 10-plex Pi3k Tmt T-cells Pi3kδ Nlc-ms/ms Cd4+ Mouse Tcr Interactome 
GenomicsGenome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, r...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17850 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (BeadChip)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarising conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71575 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (RNA-Seq)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarizing conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71645 | biostudies-arrayexpress
TranscriptomicsStat6 mediated regulation of transcription to initiate Th2 program in human T cells
This SuperSeries is composed of the following subset Series: GSE17850: Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells GSE17851: Genome-wide analysis of STAT6 target genes in IL-4 treated human cord blood CD4+ cells GSE17974: Genome-wide analysis of early transc...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-18017 | biostudies-arrayexpress
ProteomicsIn-depth analysis of the phosphoprotein landscape of cytotoxic T lymphocytes and its regulation by cytokines
Here we present high-resolution mass spectrometry analysis of changes to the phosphoproteome of cytotoxic T lymphocytes (CTL) induced by the cytokine, Interleukin 12 (IL-12). We treated CTL with a short and long IL-12 stimulation and mapped the changes to the phosphoproteome using quantitative SILAC...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-24 | PXD004644 | Pride
Silac Il-12 Phosphoproteomics Lymphocytes 
ProteomicsPhosphoproteomic analyses of IL-2 signaling reveals integrated JAK-dependent and independent phosphorylation networks that drive cytotoxic T cell fate
High-resolution mass spectrometry analysis of Interleukin 2 (IL-2) and Janus kinase (JAK) controlled protein phosphorylations in cytotoxic T lymphocytes (CTL) revealed JAKs coupled IL-2 receptors to diverse and complex serine/threonine kinase-substrate networks. These involved intricate, co-ordinate...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-25 | PXD004645 | Pride
Lck/fyn Lymphocytes. Silac Jak1 Il-2 Jak3 Phosphoproteomics 
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