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ProteomicsEpitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) - part 2
Antigen-antibody interactions play a key role in the immune response post vaccination and the mechanism of action of antibody-based biopharmaceuticals. 4CMenB is a multicomponent vaccine against Neisseria meningitidis serogroup B in which factor H binding protein (fHbp) is one of the key antigens. I...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047712 | Pride
Pab Fhbp Hdx-ms 
ProteomicsEpitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)
Antigen-antibody interactions play a key role in the immune response post vaccination and the mechanism of action of antibody-based biopharmaceuticals. 4CMenB is a multicomponent vaccine against Neisseria meningitidis serogroup B in which factor H binding protein (fHbp) is one of the key antigens. I...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD046572 | Pride
Polyclonal antibodies Pab Fhbp Hdx-ms 
ProteomicsHDX-MS of Human Histidine Rich Glycoprotein (HRG)
Histidine rich glycoprotein (HRG) is a multi-domain plasma glycoprotein, which is implicated in numerous biological processes including immune regulation, angiogenesis, coagulation and fibrinolysis. Despite a diverse role of biological functions, structural investigations into HRG have yielded only ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-11-06 | PXD065786 | Pride
Hrg Hdx-ms 
ProteomicsInvestigation of GPCR-G protein coupling by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) : the GPBAR1 case.
G protein-coupled receptors (GPCRs) are key classes of proteins for drug discovery research as many of them are still orphans and their function poorly known. Their activation mechanism is roughly divided in two states : active and unactive states however related dynamics to switch from one state to...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD047827 | Pride
Cryo-em Gpbar1 G protein Gpcr-g protein Tgr5 Hdx-ms Gpcr 
ProteomicsInvestigation of the FcRn:IgG interaction by HDX-MS
Immunoglobulin Gs (IgGs) have become highly successful drug scaffolds by combining very specific target binding with the ability to induce cellular cytotoxicity. Of further advantage, IgGs possess unusually long half-lives in the blood (2-3 week). IgGs achieve such extraordinary half-lives through a...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD044285 | Pride
Ms  protein-protein interaction  mass spectrometry Hdx-ms 
ProteomicsIdentification of the epitope recognized by a specific VHH raised against the Th17 antigen (AID45212)
Segmented filamentous bacteria (SFB) are ubiquitous intestinal commensals that promote immune system development and pathogen protection. The unicellular teardrop-shaped SFB, called intracellular offsprings (IOs), attach to ileal epithelial cells via their unique tip structure and outgrow into filam...
ORGANISM(S): Escherichia coli 
2025-10-21 | PXD060041 | Pride
Segmented filamenteous bacteria (sfb) Hydrogen/deuterium exchange mass spectrometry (hdx-ms) Epitope mapping Th17 antigen (aid45212) 
ProteomicsAn HDX-MS optimised approach to characterise nanobodies as tools for biochemical and structural studies
Given the far-reaching applications of nanobodies, a stream-lined approach to characterizing nanobodies tailored to its intended application is warranted. Camelids can produce a large number of antibodies that can bind to a host of epitopes spanning the entire protein of interest, making identificat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025207 | Pride
Hdx-ms Pi3k Nanobody 
ProteomicsHuman Calcitonin and Amylin receptor HDX-MS
Receptor activity-modifying proteins (RAMPs) regulate the pharmacology, trafficking, and signaling of class B1 G protein-coupled receptors (GPCRs). The calcitonin receptor (CTR) interacts with each of the three RAMPs to form amylin receptors (AMYRs), which display distinct ligand preferences and sig...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD068848 | Pride
Calcitonin recepto Hdx-ms Recepror activity modifying protein (ramp) Gpcr Amylin receptor 
ProteomicsInvestigating the dynamics of the SecA–SecYEG complex dynamic by HDX-MS
We employ hydrogen-deuterium exchange mass spectrometry (HDX-MS) to investigate the conformational dynamics required to facilitate based Brownian ratchet mechanism for protein secretion (by the SecA-SecYEG complex).
ORGANISM(S): Escherichia coli 
2019-07-16 | PXD013594 | Pride
Seca–secyeg Hdx-ms 
ProteomicsComparative analysis of the structural dynamics of diphtheria toxin and CRM197 carrier proteins used in the development of conjugate vaccines
Carrier proteins are chemically linked to poorly immunogenic antigens to generate conjugate vaccines, which have significantly improved immunization strategies in recent decades. CRM197, a genetically detoxified diphtheria toxin (DT) mutant carrying the G52E mutation, is a widely used carrier protei...
ORGANISM(S): Escherichia coli Corynebacterium diphtheriae 
2025-04-07 | PXD057388 | Pride
Comparative analysis Crm197 Structural characterization Hydrogen/deuterium exchange mass spectrometry (hdx-ms) Biopharmaceutical products 
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