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TranscriptomicsscRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue
Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition ...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10662 | biostudies-arrayexpress
ProteomicsLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to Chromatin
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stresses. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-01 | PXD022467 | Pride
Proteomics Hnrnpr Ip Ftld Als Motoneurons Dna damage response 
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
ProteomicsVerticillium dahliae Vta3 promotes ELV1 virulence factor gene expression in xylem sap, but tames Mtf1-mediated late stages of fungus-plant interactions and microsclerotia formation
Verticillium transcription activator of adhesion 3 (Vta3) is required for plant root colonization and pathogenicity of the soil-borne vascular fungus Verticillium dahliae [Bui et al., 2018]. In this study, we discovered that Vta3 contributes to the virulence of V. dahliae on tomato plants by promoti...
ORGANISM(S): Verticillium dahliae JR2 
2023-01-18 | PXD039123 | Pride
Verticillium dahliae Master transcription factor 1 Jr2 Mtf1 Transcription factor Vta3 Verticillium transcription activator of adhesion 3 
UnknownR-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development.
Not available
S-EPMC9283295 | biostudies-literature
TranscriptomicsSingle cell RNA sequencing of iPSC-derived lung organoid models
Here, we used single cell RNA sequencing of iPSC17 WT 7B2-derived day 10 lung spheroids, unsorted 3-, 6-, and 10-week lung progenitor organoids (LPOs) and induced bud tip progenitor organoids (iBTOs) sorted from 4- and 10-week LPOs, sequenced 4 weeks post-sort. All cultures were grown in serum-free ...
ORGANISM(S): Homo sapiens 
2022-07-24 | E-MTAB-11953 | biostudies-arrayexpress
UnknownSpotted fever group Rickettsia, Anaplasma and Coxiella-like endosymbiont in Haemaphysalis ticks from mammals in Thailand.
Not available
S-EPMC9684344 | biostudies-literature
ProteomicsMulti-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds
Fusarium Head Blight (FHB) is a devastating fungal disease of small grain cereals like wheat and barley, causing substantial yield and quality losses each year worldwide. FHB is caused by Fusarium species that produce mycotoxins such as deoxynivalenol (DON) that impairs protein biosynthesis. Althoug...
ORGANISM(S): Hordeum vulgare (Barley) 
2026-05-18 | PXD068736 | Pride
Barley Fusarium head blight 
UnknownThe Efficacy and Safety of Oral Irrigator on the Control of Dental Plaque and Gingivitis: A Randomized, Single-Blind, Parallel-Group Clinical Trial.
Not available
S-EPMC9965011 | biostudies-literature
UnknownGogo receptor contributes to retinotopic map formation and prevents R1-6 photoreceptor axon bundling.
Not available
S-EPMC3691217 | biostudies-literature
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