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ProteomicsRadioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, provides quantitative insights into organ-scale pathophysiology, generating digital disease fingerprin...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052594 | Pride
Interstitial lung disease Radiomics Proteomics Multiomics Imaging Lung fibrosis Nintedanib 
ProteomicsDIA LC-MSMS of MCF-7 Breast Cancer Cells
The breast cancer cell line MCF-7 was treated with doxorubicin. Protein expression differences between treated and non-treated cells were semiquantitatively determined using the precursor acquisition independent from ion count (PAcIFIC) mass spectrometric method. The acquired proteomic data sets wer...
ORGANISM(S): Homo sapiens (Human) 
2015-11-09 | PXD002998 | Pride
Lc-msms Pacific Data-independent acquisition Mcf-7 
ProteomicsProfiling of Human Circulating Plasma Microparticle Associated Proteins by DDA and DIA
Cells of the vascular system release spherical vesicles, called microparticles (MP), in the size range of 0.1-1μm induced by a variety of stress factors resulting in variable MP concentrations between health and disease. Furthermore, MP have intercellular communication/signaling properties and inter...
ORGANISM(S): Homo sapiens (Human) 
2016-10-18 | PXD003935 | Pride
Human Plasma Microparticles Relative quantification 
ProteomicsAbsolute Quantification of Grapevine Red Blotch Virus in Grapevine Leaf and Petiole Tissues by Proteomics
Grapevine red blotch is a recently identified viral disease that was first recognized in the Napa Valley of California. Infected plants showed foliar symptoms similar to leafroll, another grapevine viral disease, on vines testing negative for known grapevine leafroll-associated virus. Later, the Gra...
ORGANISM(S): Vitis vinifera (Grape) 
2018-12-19 | PXD011002 | Pride
Shotgun lc-ms/ms Grapevine Grapevine red blotch virus Parallel reaction monitoring Proteomics Absolute quantification 
ProteomicsBeyond a linear structure: The Tubular of the Tripartite Attachment Complex and the Functional Role of TAC53
The tripartite attachment complex (TAC) is essential for mitochondrial DNA (kDNA) segregation in Trypanosoma brucei, providing a physical link between the flagellar basal body and the mitochondrial genome. Although the TAC's hierarchical assembly and linear organization have been extensively studied...
ORGANISM(S): Trypanosoma brucei 
2025-08-11 | PXD062506 | Pride
Tripartite attachment complex Expansion microscopy Trypanosoma brucei 
ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
ProteomicsDifferentially and constantly expressed proteins identified through proteomic analysis of different Toxoplasma gondii field isolates carried out upon short- or long-term in vitro culture
Comparison of the proteomes of Toxoplasma gondii field isolates after short-term or long-term in vitro culture
ORGANISM(S): Toxoplasma gondii 
2025-10-06 | PXD067210 | Pride
Target deconvolution Model system Patho-biodiversity Eukaryote cell Equivalence tests Vaccine development 
ProteomicsRole of Specialized Composition of SWI/SNF Complexes in Prostate Cancer Lineage Plasticity
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance seen in 10% of these patients is through lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine pros...
ORGANISM(S): Homo sapiens (Human) 
2020-11-04 | PXD016861 | Pride
Swi/snf complex Lineage plasticity Prostate cancer Epigenetic 
ProteomicsExtracellular Vesicles of Minimalistic Mollicutes as Mediators of Immune Modulation and Horizontal Gene Transfer
Extracellular vesicles (EVs) are central components of bacterial secretomes, including the small, cell wall-less Mollicutes. Although EV release in Mollicutes has been reported, EV proteomic composition and function have not been explored yet. We developed a protocol for isolating EVs of the pathog...
ORGANISM(S): Mycoplasmopsis bovis Mycoplasma mycoides 
2025-05-07 | PXD061464 | Pride
Mycoplasma Extracellular vesicles 
ProteomicsDevelopment and validation of an ELISA to measure REG3E in canine blood
Regenerating islet-derived proteins (REG) are upregulated in people with sepsis, pancreatitis, and gastrointestinal diseases. One member of the REG family, namely REG3E, was recently identified in pancreatic tissue and plasma of dogs, with high expression in pancreatitis and sepsis. Our objective wa...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-06-10 | PXD046936 | Pride
Gastrointestinal Biomarker Sepsis Canine Pancreatitis Canis lupus familiaris Pancreas 
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