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ProteomicsProteomic and cellular responses against mutagenesis
Endogenous stress represents a major source of genome instability, but is in essence difficult to apprehend. Incorporation of labeled radionuclides into DNA constitutes a tractable model to analyze cellular responses to endogenous attacks. Here we show that incorporation of [3H]thymidine into CHO ha...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2016-07-15 | PXD003542 | Pride
Endogenous stress Tritium Oxidative stress Proteomic Mutagenesis Low doses 
ProteomicsRoot membrane ubiquitinome under osmotic stress reveals specific post-translational modification patterns
Osmotic stress is detrimental for the plant which survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification (PTM) in osmotic mediated stress. Plants use the ubiquitin proteasome system to modulate protein contents required to respond to and ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-04-04 | PXD022249 | Pride
Post-translational modification Mass spectrometry Osmotic stress Ubiquitination Aquaporin 
ProteomicsSeed comparative genomics in three coffee species evidence desiccation tolerance mechanisms among intermediate seeds
In contrast to the desiccation tolerant (DT) ‘orthodox’ seeds, the so-called ‘intermediate’ seeds cannot survive complete drying and are short-lived. All species of the genus Coffea produce intermediate seeds but show a considerable variability for the seed DT level, which may help to decipher the m...
ORGANISM(S): Coffea canephora Coffea arabica (Arabian coffee) Coffea eugenioides 
2020-05-26 | PXD015806 | Pride
Dehydration Transcriptome. Intermediate seeds Respiration Coffea Late maturation Desiccation tolerance Metabolic quiescence Seed development 
ProteomicsQuantitative proteomic analysis of Toxoplasma gondii mutants of the mitochondrial and plastidic Iron sulfur cluster synthesis pathways.
Toxoplasma gondii is a parasitic protist that is the agent of toxoplasmosis. It is capable of infecting all mammals, including humans. The infection is mainly asymptomatic in immunocompetent patients, but in case of immunosuppression or for the congenital form of toxoplasmosis it can lead to severe ...
ORGANISM(S): Toxoplasma gondii RH 
2021-11-09 | PXD023854 | Pride
Iron sulfur cluster Apicoplast Mitochondrion Differentiation Bradyzoite 
ProteomicsEthylene receptor protein quantification in Solanum lycopersicum
Ethylene receptor protein quantification is essential to study their functions, but is impaired by low resolutive tools such as antibodies that are mostly nonspecific. Here we report a proteomic method that enables the quantification of all tomato ethylene receptors, which can be applied to other or...
ORGANISM(S): Solanum lycopersicum 
2019-10-11 | PXD011412 | Pride
Lethylene receptor Never ripe mutant 
ProteomicsProteomic analysis of bystander effects induced by irradiated chondrosarcoma cells
To understand the cellular response of bystander cells, we performed a 2D gel-based proteomic study of the chondrocyte receiving the conditioned medium of low dose irradiated chondrosarcoma cells. The proteomic analysis of the bystander chondrocytes highlighted 20 proteins spots that were significan...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD025187 | Pride
Proteomic analysis Chondrosarcoma Bystander signalling Secretome 
ProteomicsKi-67 organises heterochromatin during cell proliferation
Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation. Altering Ki-67 expression levels did not significantly affect cell proliferation...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003551 | Pride
Ki-67 interactome Cell proliferation Heterochromatin Mki67 Antigen ki-67 
ProteomicsHistone H3 Serine-57 phosphorylation by CHK1 promotes responses to DNA replication stress
Post-translational modifications (PTM) of chromatin control the genomic environment for transcription, DNA replication and repair in response to cell stimuli1–3. Replication stress in budding and fission yeasts leads to abundant acetylation of histone H3 on lysine-56 (H3K56ac)4–6, but only trace lev...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2022-02-10 | PXD011328 | Pride
Histone post-translational modifications H3s57ph Checkpoint kinase 1 (chk1) Chromatin Dna replication stress 
ProteomicsProject title Trypanosoma congolense s.l. natural infection induces proteome modifications in wild tsetse flies (Glossina palpalis palpalis)
Tsetse flies (Glossina spp.) are major vectors of African trypanosomes, causing either Human or Animal African Trypanosomiasis (HAT or AAT). Several approaches are developed to control the disease among which the anti-vector Sterile Insect Technique. Another approach in the frame of anti-vector stra...
ORGANISM(S): Trypanosoma brucei 
2023-07-26 | PXD034619 | Pride
Tsetse fly  trypanosomiasis  natural fly infection  differential protein expression  vector competence control. 
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