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ProteomicsSpatiotemporal resolution of α-synuclein pathology in human dopaminergic neurons implicates defective ER translocation in Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative disease, currently without any disease modifying therapy. Although α-synuclein is causatively linked to Parkinson’s pathogenesis, the primary mechanism and subcellular localisation of early cytotoxicity as well as its most damaging...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD055581 | Pride
Ribotoxicity Alpha-synuclein Parkinson’s disease Endoplasmic reticulum 
ProteomicsQuantitative secretomics identifies ligand-receptor pairs in pancreatic cancer that mediate bidirectional crosstalk between cancer stem cells and nociceptors
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest and most metastatic cancers in human. PDACs respond poorly to therapies, partly due to cancer stem cells (CSCs) that self-renew, survive chemotherapies, metastasise and replenish the tumour. Factors secreted by tumour cells mediate auto...
ORGANISM(S): Homo sapiens (Human) 
2024-04-06 | PXD046026 | Pride
Vgf nerve growth factor inducible (vgf) Pancreatic cancer Cancer stem cell (csc) Tumour growth Gemcitabine. Transforming growth factor beta (tgfβ) Growth differentiation factor 15 (gdf15) Pancreatic adenocarcinoma (pdac) 
ProteomicsThymosin 4 protects against aortic aneurysm via endocytic regulation of growth factor signalling
Vascular stability and tone are maintained by contractile smooth muscle cells (VSMCs). However, injury-induced growth factors stimulate a contractile-synthetic phenotypic modulation which increases susceptibility to abdominal aortic aneurysm (AAA). As a regulator of embryonic VSMC differentiation, w...
ORGANISM(S): Homo sapiens (Human) 
2021-05-21 | PXD024162 | Pride
Smooth muscle cells Lrp1lrp1 Thymosin β4 Vascular stability Endocytosis Abdominal aortic aneurysm Pdgfr)β signalling 
ProteomicsOncogenic Mutations of KRAS Modulate Its Turnover by the CUL3/LZTR1 E3 ligase Complex
KRAS is a proto-oncogene encoding a small GTPase. Mutations contribute up to 30% of human solid tumours including lung adenocarcinoma, pancreatic and colorectal carcinomas. Most KRAS activating mutations interfere with GTP hydrolysis, essential for its role as a molecular switch, leading to alterati...
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD029725 | Pride
G13d Kras G12d 
ProteomicsA new NO-independent immunomodulatory function for iNOS in regulating itaconate production via mitochondrial protein-protein interaction with IRG1
iNOS modulates itaconate metabolism by a novel conformation-dependent protein-protein interaction separate from iNOS-mediated NO generation.
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD048712 | Pride
Macrophages Tca cycle by cis-aconitate decarboxylase Inos and irg1 
ProteomicsAn unconventional integrin b3 and CD103 heterodimer improves the anti-tumor immunity of tissue-resident T cells
Current cancer immunotherapies promote recovery of CD103+ tissue-resident memory T cells (Trm) population of the tumor-infiltrating T lymphocytes (TILs). However, not all treated patients exhibit improved anti-tumor immunity and survival, likely due to the immunophenotypical diversity among the C...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD031794 | Pride
Xcr1 Granulysin Itgb3 Tissue-resident Cancer immunotherapy Amino acids Cancer-specific t cells 
ProteomicsLC-MS/MS analyses of purified virions of influenza A and B viruses, grown in a range of hosts.
LC-MS/MS analyses of purified virions of influenza A and B viruses, grown in a range of hosts. Described in Hutchinson et al. 'Conserved and host-specific features of influenza virion architecture.'
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Canis Familiaris (canine) Influenza Viruses Gallus Gallus (ncbitaxon:9031) 
2014-06-16 | MSV000078740 | MassIVE
MetabolomicsGrowth control of the eukaryote cell: a systems biology study in yeast
Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each function...
2012-04-19 | MTBLS8 | MetaboLights
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