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ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027330 | Pride
Human Pr619 Tak243 U2os His10-ub Ubiquitin Mg132 
ProteomicsSUMOYLATION AND PROTEOTOSASIS NETWORKS CONVERGE DURING HEAT SHOCK TO MINIMIZE AGGREGATION AND PROMOTE DEGRADATION OF NUCLEAR PROTEINS
The role of stress-induced increases in SUMO2/3 conjugation during the Heat Shock Response (HSR) has remained enigmatic. We investigated SUMO signal transduction at the proteomic and functional level during the HSR in the context of cells depleted of proteostasis network components via chronic Heat ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD010231 | Pride
Heat shock Hsf1 Small ubiquitin-like modifier Proteostasis Sumo 
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