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UnknownOverexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619.
Not available
S-EPMC8464711 | biostudies-literature
UnknownImmunogenic cell death triggered by impaired deubiquitination in multiple myeloma relies on dysregulated type I interferon signaling.
Not available
S-EPMC10018035 | biostudies-literature
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027328 | Pride
Human Ubisite Pr619 Tak243 U2os Ubiquitin Mg132 
UnknownDeubiquitinating Enzyme Inhibitors Block Chikungunya Virus Replication.
Not available
S-EPMC9966916 | biostudies-literature
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027330 | Pride
Human Pr619 Tak243 U2os His10-ub Ubiquitin Mg132 
UnknownHistone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1.
Not available
S-EPMC6237452 | biostudies-literature
UnknownDeubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.
Not available
S-EPMC4662625 | biostudies-literature
ProteomicsThe inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential
Interleukin-1B (IL-1B) is pathologically activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in wide-spread diseases. Therefore, IL-1B activity must be fine-tuned to enable anti-microbial responses whilst limiting collateral damage. Here we report that, relative to...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD021305 | Pride
Interleukin-1 Caspase-1 Inflammation Inflammasome Toll-like receptor Proteasome Caspase-8 Ubiquitin 
ProteomicsProteomes and Ubiquitylomes Analysis Reveals the Involvement of Ubiquitination in Protein Degradation
Petal senescence is a complex programmed process. It has been previously demonstrated that treatment with ethylene, a plant hormone involved in senescence, can extensively alter transcriptome and proteome profiles in plants. However, little is known regarding the impact of ethylene on post-tra...
ORGANISM(S): Petunia hybrida (Petunia) 
2020-03-20 | PXD005470 | Pride
Ethylene  ubiquitination  senescence  petunia  protein degradation lc-msms 
ProteomicsIdentification of TNFRSC (TNF receptor signalling complex) members in DIA
TNFR signalling complex (TNFRSC) pulldown and DDA analysis with 2 controls (HIS_TNFalpha, Unstimulated)
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD019877 | Pride
Ap-ms Tnf-rsc Dia 
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