Sort   by:  
 Page size 
ProteomicsAbsolute quantification of TNF-RSC members from isolated TNF-RSC from A549 cells
Determination of absolute abundance of TNF-RSC members in the isolated TNF-RSC.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD019879 | Pride
Ap-ms Aqua Prm Tnf-rsc 
ProteomicsAbsolute quantification and copy number estimation of the TNF-RSC members in A549 cells
Determine the copy number per cell of the TNF-RSC members in A549 cells using targeted proteomics (PRM) combined with spike-in of known amounts of reference peptides.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD019959 | Pride
Aqua Prm Copy number Tnf-rsc 
ProteomicsEffect of UBASH3B and WHIP genetic deletion on the TNF-RSC
Determination of TNF-RSC composition in UBASH3B and WHIP KOs.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD019903 | Pride
Dda Ap-ms Tnf-rsc 
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
PXD037648 |
ProteomicsSPATA2 links CYLD to the TNF-a receptor signaling complex and modulates the receptor signaling outcomes
TNF-a is a key regulator of innate immune and proinflammatory responses. However, the composition of the TNF-a receptor associated signaling complexes (TNF-RSC) and the architecture of the downstream signaling networks are incompletely understood. We employed quantitative mass spectrometry to demons...
ORGANISM(S): Homo sapiens (Human) 
2016-06-09 | PXD003627 | Pride
Necroptosis Tnf-alpha Nf-kappab Phosphorylation Ubiquitin 
UnknownABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Not available
S-EPMC5741489 | biostudies-literature
ProteomicsSPATA2 links CYLD to the TNF-a receptor signaling complex and modulates the receptor signaling outcomes
TNF-a is a key regulator of innate immune and proinflammatory responses. However, the composition of the TNF-a receptor associated signaling complexes (TNF-RSC) and the architecture of the downstream signaling networks are incompletely understood. We employed quantitative mass spectrometry to demons...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080842 | MassIVE
ProteomicsBlue Native Page based separation of the TNFRSC
Separation and relative quantification by targeted mass spectrometry of the TNFRSC members pior and after treatment with a generic deubiquitinating enzyme
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD019847 | Pride
Bn page tnfrsc prm 
ProteomicsQuantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death
TNFα is a potent inducer of inflammation due to its ability to promote gene expression, inpart via the NFκB pathway. Moreover, in some contexts, TNFα promotes Caspase-dependent apoptosis or RIPK1/RIPK3/MLKL-dependent necrosis. Engagement of the TNF Receptor Signaling Complex (TNF-RSC), which contain...
ORGANISM(S): Homo sapiens (Human) 
2017-05-30 | PXD006055 | Pride
Inflammatory response Cellular signaling Cell death Mass spectrometry Phosphoproteome 
UnknownSPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes.
Not available
S-EPMC5007551 | biostudies-literature
Sort   by:  
 Page size