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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
ProteomicsHistidine methylation of MYLK2 and C3H zinc fingers by CARNMT1
We here describe our independent uncovering of CARNMT1 as a protein histidine methyltransferase (HMT), and our extensive efforts on defining its substrate specificity and methylation targets. We found that recombinant CARNMT1 methylated MYLK2-derived peptide containing His-148 in vitro. The recombin...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2025-07-28 | PXD060821 | Pride
C3h zinc finger 1mh 1-methylhistidine Mylk2 Spliceosome Histidine methyltransferase Rnf113a Protein methylation Carnmt1 U2af1 
ProteomicsNovel roles for ribosomal histidine methylation revealed by proteomics and large-scale cross-linking mass spectrometry
The methylation of histidine residues is increasingly found to be both prevalent throughout the proteome, and also relevant to human disease. Hpm1p mono-methylates H243 in the ribosomal protein Rpl3 and represents the only histidine methyltransferase in Saccharomyces cerevisiae. Interestingly, the h...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-12 | PXD027953 | Pride
Cross-linking Yeast Silac Histidine methylation 
ProteomicsProSeAM SILAC MS screening for METTL18 substrates
Click chemistry based substrates screening for METTL18 in Mettl18 KO HEK293T cells.
ORGANISM(S): Homo Sapiens (human) 
2022-06-09 | PXD026813 | JPOST Repository
ProteomicsProtein methylation analysis of Jurkat cells
Protein methylation, especially in arginine and lysine, is one of most important post-translational modifications (PTMs). In this project, we developed a novel chemical strategy which enabled almost complete depletion of histidine-conatining peptides in protein digestion and thereby resulted in the ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-08 | PXD023845 | Pride
Protein methylation 
GenomicsHistidine-dependent protein methylation is required for compartmentalization of CTP synthase
Histidine-dependent protein methylation is required for compartmentalization of CTP synthase
PRJNA415056 | ENA
GenomicsMETTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
PRJNA745343 | ENA
GenomicsMETTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance.
METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance.
PRJNA823531 | ENA
ProteomicsProteomic Analysis of Protein Methylation in the Yeast Saccharomyces cerevisiae
Protein methylation catalyzed by SAM-dependent methyltransferase represents a major PTM involved in important biological processes. Because methylation can occur on nitrogen, oxygen and sulfur centers and multiple methylation states exist on the nitrogen centers, methylproteome remains poorly docume...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-01-27 | PXD000606 | Pride
Lc/ms/ms Methylation Proteomics Saccharomyces cerevisiae 
TranscriptomicsMETTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance.
Protein methylation occurs predominantly on lysine and arginine residues, but histidine also serves as a substrate for the modification. However, a limited number of enzymes responsible for this modification have been reported. Moreover, the biological role of histidine methylation has remained poor...
ORGANISM(S): Homo sapiens 
2022-06-15 | GSE200172 | GEO
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