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ProteomicsShotgun mass-spectrometry of HL-60 cell proteins for spectrum library development
ATRA-induced differentiation of HL-60 cells was studied using targeted mass-spectrometry including selected reaction monitoring (SRM) and parallel reaction monitoring (PRM) approach. PRM experiment was performed in time-course manner, without peptide standards usage. PRM data was inspected in Skylin...
ORGANISM(S): Homo sapiens (Human) 
2017-11-09 | PXD006421 | Pride
Orbitrap velos Atra Differentiation Hl-60 cell line 
ProteomicsHL-60 clone 15 differentiation LC-MS
As eosinophils are the densest and lowest abundant leukocytes, their isolation is cost-and labor intense. This sets restrictions on many aspects of eosinophilic research. Eosinophilic cell lines are available for use; however they are not characterized in much detail, yet. Cells of the HL-60 clone 1...
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD057747 | Pride
Human Differentiation Neutrophils Lc-ms Eosinophils Hl-60 clone 15 
TranscriptomicsRNA-seq analysis of neutrophils from CD40L-deficient patients and healthy controls, as well as HL-60 promielocytic cell line
We aim to characterize to effects of the absence of CD40L on neutrophil transcriptome and the effect of soluble CD40L on HL60 cells. For this purpose Total RNA of isolated neutrophils from three CD40L-deficient patients and three healthy controls as well as HL-60 cells from ATCC (HL-60 (ATCC CCL-240...
ORGANISM(S): Homo sapiens 
2017-03-14 | E-MTAB-5316 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human AML cell line, HL-60 and its mitoxantrone resistant subline HL60/MX2
Alteration in metabolic repertoire is commonly associated with resistance phenotype. Although it’s a common phenotype, not much efforts have been undertaken to design effective strategies to target the metabolic drift in such cancerous cells and especially with drug resistant properties. In our stud...
ORGANISM(S): Homo sapiens 
2021-01-01 | E-MTAB-8981 | biostudies-arrayexpress
GenomicsSequencing Apoptotic DNA Breakpoints
DNA fragmentation is a well-recognized hallmark of apoptosis. However, the precise DNA sequences cleaved during apoptosis triggered by distinct mechanisms remain unclear. We used next-generation sequencing of DNA fragments generated in Actinomycin D-treated human HL-60 leukemic cells to generate a h...
ORGANISM(S): Homo sapiens 
2011-10-15 | E-GEOD-32997 | biostudies-arrayexpress
TranscriptomicsTranscriptomic effects of Capridine on the acute promyelocytic leukemia HL-60 cell line
We used Agilent human gene expression arrays to test whether Capridine, a chemotherapeutic agent with specificity towards prostate cancer, deregulates the genomic fabric of acute myeloyd leukemia in HL-60 cells. This cell line was derived at the National Cancer Institute from a 36-year-old woman wit...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-72415 | biostudies-arrayexpress
TranscriptomicsThe effect of MPO inhibitor on the gene expression profiles in HL-60 cell lines exposed to 1, 2, 4,-benzenetriol
To reveal the gene expression profile changes after exposure to BT, one of benzene metabolites, with or without ABAH, a myeloperoxidase (MPO) inhibitor, and to elucidate how MPO is involved in myelotoxicity of BT, we performed microarray analysis. HL-60 cells suspended in RPMI 1640 containing with 1...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-50805 | biostudies-arrayexpress
TranscriptomicsRNA seq of HL-60 cells in untreated, ATRA (All- trans retinoic acid) and Vitamin D3 treated conditions
The leukemic cell line HL-60 is widely used to study normal and aberrant myelopoiesis. HL-60 cells can be treated with ATRA (all-trans retinoic acid) and Vit-D3 (1,25-Dihydroxyvitamin D3) to differentiate into granulocytes and monocytes respectively. Induced myeloid differentiation helps us to under...
ORGANISM(S): Homo sapiens 
2023-01-25 | E-MTAB-12267 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HL-60 cells treated with anacardic acid
The aim of the experiment was to identify the genes up or downregulated by hyposumoylation induced by anacardic acid, an inhibitor of SUMO activating enzyme, in Acute Myeloid Leukemia cell line HL-60
ORGANISM(S): Homo sapiens 
2014-06-11 | E-MTAB-2382 | biostudies-arrayexpress
TranscriptomicsNeutrophil-derived pro-inflammatory cytokine response and degranulation in function of time and dose of LPS treatment.
The purpose of the present study was to elucidate in more details the molecular mechanisms of neutrophil-mediated inflammation. We therefore investigated the time-dependent stimulatory potential of LPS from Escherichia coli on cytokine response in neutrophil-like HL-60 cells.

To get a genera...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-MTAB-1393 | biostudies-arrayexpress
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