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ProteomicsMistranslating tRNA variants impact on the proteome and phosphoproteome of Saccharomyces cerevisiae – phosphoproteome DDA and DIA data
Mutations in tRNAs can lead to mis-incorporation of an amino acid into a growing polypeptide chain that differs from what is specified by the mRNA in a process known as mistranslation. As mistranslating tRNAs modify how the genetic message is decoded, they have potential as therapeutic tools to trea...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-11-18 | PXD068388 | Pride
Phosphoproteome Translation fidelity Trnas Saccharomyces cerevisiae Mistranslation Yeast 
ProteomicsMistranslating tRNA variants impact on the proteome and phosphoproteome of Saccharomyces cerevisiae – whole proteome DDA and DIA data
Mutations in tRNAs can lead to mis-incorporation of an amino acid into a growing polypeptide chain that differs from what is specified by the mRNA in a process known as mistranslation. As mistranslating tRNAs modify how the genetic message is decoded, they have potential as therapeutic tools to trea...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-11-18 | PXD068392 | Pride
Translation fidelity Trnas Saccharomyces cerevisiae Mistranslation Proteome Yeast 
TranscriptomicsMapping genetic modifiers of ARPKD
Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene in both humans and the orthologous PCK rat model. Although ARPKD results solely from PKHD1 mutations, the disease onset and severity are highly variable, indicating that other unknown genetic risk factor(s...
ORGANISM(S): Rattus norvegicus 
2015-06-06 | E-GEOD-58229 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae paf1 and ctr9 mutants to identify direct targets of the Paf1/RNA polymerase II complex
To identify the direct targets of the Paf1/RNA polymerase II complex we compared expression profiles of isogenic wild type and paf1 and ctr9 mutant strains. We also created a Tet-regulated form of Paf1 and monitored expression patterns after shut off of Paf1. Samples were isolated at one hour interv...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-19 | E-GEOD-3200 | biostudies-arrayexpress
ProteomicsPhosphorylation of Cohesin's Deposition Factor, Scc2 Regulates its Deposition Activity
Phosphorylated residues of the budding yeast Scc2 protein were identified using phosphopeptide enrichment and mass spectrometry.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-09-10 | PXD001830 | Pride
Nipbl Scc2 Delangin Cohesin Sister chromatid cohesion 
TranscriptomicsSMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
Characterization of the selectivity of SMN splicing modifiers in SMA type I fibroblasts by RNASeq In total 12 samples were analyzed, divided into four distinct groups (treated with SMN-C3 @ 500 nM; controls for SMN-C3; treated with SMN-C1 @ 100 nM; controls for SMN-C1) containing 3 replicates each.
ORGANISM(S): Homo sapiens 
2014-10-22 | E-GEOD-62540 | biostudies-arrayexpress
UnknownMetabolic shift underlies recovery in reversible infantile respiratory chain deficiency
Not available
S-SCDT-EMBOJ-2020-105364-T | biostudies-other
GenomicsCohort-Based Genome-Wide Association Study of Glioma (GliomaScan)

We conducted a new independent GWAS of adult glioma using 1,856 cases and 4,955 controls from 14 cohort studies belonging to the Cohort Consortium, 3 case-control studies, and 1 population-based case only study. Cases were newly diagnosed glioma [ICDO-3 codes 9380-9480 or equivalent], and control...

phs000652.v1.p1 | EGA
Genomicsuk10k_rare_neuromuscular_rel_2012_11_27-sc-20121218 - samples
UK10K_RARE_NEUROMUSCULAR REL-2012-11-27
EGAD00001000298 | EGA
Genomicsuk10k_rare_neuromuscular_rel_2012_01_13-sc-20120611 - samples
UK10K_RARE_NEUROMUSCULAR REL-2012-01-13
EGAD00001000180 | EGA
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