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ProteomicsQuantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures – mouse bone marrow, blood and peritoneal cavity neutrophils
Neutrophils are one of the first responders to infection and are a key component of the innate immune system through their ability to phagocytose and kill invading pathogens, secrete antimicrobial molecules and produce extracellular traps. Neutrophils are produced in the bone marrow, circulate withi...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-13 | PXD044568 | Pride
Proteomics Tissue-resident Neutrophils Infection 
ProteomicsQuantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures – human blood neutrophils
Neutrophils are one of the first responders to infection and are a key component of the innate immune system through their ability to phagocytose and kill invading pathogens, secrete antimicrobial molecules and produce extracellular traps. Neutrophils are produced in the bone marrow, circulate withi...
ORGANISM(S): Homo sapiens (Human) 
2024-03-13 | PXD044569 | Pride
Proteomics Tissue-resident Neutrophils Infection 
ProteomicsThe proteome of B cell maturation identifies PDCD4 as limiting the response of marginal zone B cells – WT and PDCD4 KO MZ B cells. Includes Fasta file
During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. We used high-resolution mass spectrometry to quantify the proteome of B cell subsets from the mouse spleen and map the diffe...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-29 | PXD043351 | Pride
B cells Pdcd4 
ProteomicsSynaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons - second data set
Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. The morphology, connectivity, electrophysiological properties, and role in behavior of these neurons have been extensively analyzed. However, the molecular composi...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD052081 | Pride
Neurons Synapses 
ProteomicsCortical layer 5 neuron-specific synaptic protein profiling suggests differential vulnerability to neurodevelopmental disorders
Pyramidal neurons in the cortex are embedded in distinct information processing pathways. Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons receive different input and project to distinct brain regions. The synaptic molecular signatures that define synaptic connectivity ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-04 | PXD046812 | Pride
Synaptic proteome Neurodevelopment Turboid 
ProteomicsAmino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses - SLC7A5 and SLC7A8 KO
Group 2 innate lymphoid cells (ILC2) are functionally poised, tissue-resident lymphocytes that respond rapidly to damage and infection at mucosal barrier sites. ILC2 reside within complex microenvironments where they are subject to cues from both the diet and invading pathogens – including helminths...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-22 | PXD038786 | Pride
Ilc2 Immunology 
ProteomicsAmino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses - WT ILC2
Group 2 innate lymphoid cells (ILC2) are functionally poised, tissue-resident lymphocytes that respond rapidly to damage and infection at mucosal barrier sites. ILC2 reside within complex microenvironments where they are subject to cues from both the diet and invading pathogens – including helminths...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-22 | PXD038792 | Pride
Ilc2 Immunology 
ProteomicsA type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus induced disease 2019 (COVID-19). Neutrophils play a key role in the lung injury characteristic of non-COVID-19 A...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023834 | Pride
Ards Type i ifn Sars-cov-2 Dexamethasone Neutrophil Covid-19 
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