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TranscriptomicsGenome-wide transcriptome analysis of two maize inbred lines under drought stress during the seedling stage
To understand the transcriptome changes during drought tolerance in maize, the drought-tolerant line Han21 and drought-sensitive line Ye478, which show substantial differences in drought tolerance at the seedling stage, were selected for this study. Using the GeneChip Maize Genome Arrays, we applied...
ORGANISM(S): Zea mays 
2010-06-16 | E-GEOD-16567 | biostudies-arrayexpress
ProteomicsASF1 acts with RIF1 to promote DNA end-joining in BRCA1 deficient cells
RIF1 acts downstream of 53BP1 to coordinate DNA double strand break repair pathway choice between non-homologous end joining (NHEJ) and homologous recombination (HR). Here we identified ASF1 as an endogenous RIF1-associated protein. We showed that ASF1 forms complex with RIF1 and regulates RIF1-depe...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027727 | Pride
Rif1 Tap-ms Asf1 Interactome 
ProteomicsDIA quantitative protein mass spectrometry of RBE cells knockout NAT10
To further explore the role of NAT10 in ICC, we constructed stable NAT10-knockdown RBE cells using shRNA and performed DIA quantitative proteomic analysis to explore its influence on downstream protein fuction.
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD058708 | Pride
Intrahepatic cholangiocarcinoma nat10 dia 
ProteomicsOTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR
To explore the underlying mechanism by which OTUD6A induces PCa progression, we identified its binding proteins with an immunoprecipitation (IP)-mass spectrometry (MS) approach in two CRPC cell lines.
ORGANISM(S): Homo Sapiens 
2022-01-28 | PXD031307 |
ProteomicsIdentifying interaction proteins of METTL3 and METTL14 using APEX2-based labeling and mass spectroscopy
During translation, protein quality control systems play an active role in ensuring the proper folding and assembly of proteins. To investigate the auxiliary factors that facilitate the folding and assembly of METTL3-METTL14, we employed proximity labeling technology using the split APEX2 system
ORGANISM(S): Homo Sapiens 
2025-12-05 | PXD071685 |
ProteomicsGlioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4
Almost all high-grade gliomas, particularly glioblastoma (GBM), are highly migratory and aggressive. Migrasomes are organelles produced by highly migratory cells capable of mediating intercellular communication. Thus, GBM cells may produce migrasomes during migration. However, it remains unclear whe...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057558 |
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
2024-10-03 | PXD056593 |
ProteomicsMass spectrometry with DIA quantification of cerebrospinal fluid in 20 subarachnoid hemorrhage patients
We applied mass spectrometry with DIA quantification to identify biomarker candidates in CSF samples from a well-characterized cohort consisted of 20 SAH patients.
ORGANISM(S): Human Csf-associated Densovirus 
2022-03-08 | PXD032118 |
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062097 |
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-mass spectrometry
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062096 |
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