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ProteomicsPRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core
In the study, we identified protein arginine methyltransferase 5 (PRMT5) as a novel restriction factor of HBV replication. We have also demonstrated that PRMT5 can interact with the HBV core and methylate its arginine residues within arginine-rich domain. We identified two types of HBc post-translat...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2017-11-01 | PXD006828 | Pride
Ubiquitination Hepatitis b virus Arginine methylation Phosphorylation Hbv core protein 
ProteomicsHepatitis B Core Protein is Posttranslationally Modified through K29-linked Ubiquitination
Hepatitis B virus (HBV) core protein (HBc) plays many roles in the HBV life cycle such as regulation of transcription, RNA encapsidation, reverse transcription and viral release. To accomplish these functions, HBc interacts with many host proteins and undergoes different posttranslational modificati...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2020-12-01 | PXD021712 | Pride
Hepatitis b virus  hbc  posttranslational modifications  ubiquitination  ubiquitin  e3 ubiquitin-protein ligase 
ProteomicsHuman complement factor 3 LC-MS/MS
Purification of native complement factor 3 from human serum and proteolytic generation of activation fragments
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036611 | Pride
C3 Human serum Complement 
ProteomicsExpanding the CarD interaction network: CrsL is a novel transcription factor in Mycobacterium smegmatis
Bacterial transcription is a tightly regulated process critical for gene expression, adaptation and cell survival. CarD is an essential transcription factor in mycobacteria involved in regulation of gene expression. Here, we searched for CarD interaction partners in the model organism Mycobacterium ...
ORGANISM(S): Mycobacterium smegmatis 
2025-12-22 | PXD058166 | Pride
Msmeg_5890 Rnap Actinobacterial transcription factors Mycobacterium smegmatis Card interaction partners Crsl Apeb Msmeg_5828 
ProteomicsA protein expression during development of S. coelicolor in liquid medium
In this paper we analyzed the S.coelicolor proteome at four points in time as it grew in liquid medium s i using three biological and two technical replicates. The proteome was measured during exponential growth and its entry into the stationary phase at 20, 35, 50 and 65 hours. Differential expres...
ORGANISM(S): Streptomyces coelicolor 
2020-04-27 | PXD014338 | Pride
Swath ms 
ProteomicsMoaB2 binds to SigA in Mycobacterium smegmatis and modulates its activity and biological stability
In mycobacteria, SigA is the primary sigma factor. This essential protein binds to RNA polymerase (RNAP) and is responsible for initiating transcription of housekeeping genes. Our knowledge about this factor in medicinally important mycobacteria is limited. Here, we performed an unbiased search for ...
ORGANISM(S): Mycolicibacterium smegmatis MKD8 
2024-11-11 | PXD039468 | Pride
Mycobacteria Transcription Rna polymerase Siga Moab2 
ProteomicsComparative Label-free Quantification of Changes in the Proteome and Secretome of Hepatocytes Infected with Hepatitis B Virus in Vitro
Hepatitis B virus (HBV) infection induces changes in the host cell proteome. Using label-free differential proteomics, we investigated changes in protein levels in HepG2NTCP hepatoma cells and primary human hepatocytes (PHH) following in vitro HBV infection. Our analysis revealed significant differe...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2025-11-17 | PXD053792 | Pride
Enrichment analysis Proteomics Hepatitis b virus Vitronectin Hepatocyte Data-independent acquisition 
ProteomicsProteomic characterization of plasma membrane-enriched fraction from tobacco (Nicotiana tabacum L. cv Samsun) pollen tubes.
Pollen germination and subsequent pollen tube elongation are essential for successful land plant reproduction. These processes are achieved through well-documented activation of membrane trafficking and cell metabolism. Despite this, our knowledge of the dynamics of cellular phospholipids remains sc...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2022-10-27 | PXD037046 | Pride
Pollen tube Tobacco Tip growth Plasma membrane Polarity Pollen 
ProteomicsWhole proteome analysis of germinating Bacillus subtilis 168
In this work we present proteomic analysis of Bacillus subtilis 168 trp+ (BSB1) during germination and spore outgrowth. Samples were collected from 14 different time points (from 0 to130 minutes) after inoculation of spores into germination medium. In summary, 2,195 proteins were identified and clus...
ORGANISM(S): Bacillus subtilis 
2024-07-29 | PXD048690 | Pride
Bacillus subtilis Germinating Proteomic analysis 
ProteomicsBiogenesis of hepatitis B virus e antigen is driven by translocon-associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence
Hepatitis B virus (HBV) uses e antigen (HBe) which is dispensable for virus infectivity to modulate host immune responses and to achieve viral persistence in human hepatocytes. The HBe precursor (p25) is directed to the endoplasmic reticulum (ER), where cleavage of the signal peptide (sp) gives rise...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2022-07-01 | PXD025430 | Pride
Hbe Er translocation Hepatitis b virus Hbv precore protein Trap complex Signal peptide Cysteine residues 
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