Sort   by:  
 Page size 
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
ProteomicsIdentification of NPGPx-interacting proteins in activated T cells
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-25 | PXD017046 | Pride
T cell activation Zap70 Npgpx 
TranscriptomicsScRNA/TCR-seq of T cells from EMT6 tumors treated with aTGFb/aPD-L1
We performed 10x single cell RNA and VDJ sequencing on sorted T cells (7AAD- Calcein blue+ CD45+ THY1.1- TCRb+) in an orthotopic EMT6 tumor model 7 days after treatment initiation in four experimental groups: 1) Control 2) aPD-L1 3) aTGFb 4) aPD-L1 and aTGFb.
ORGANISM(S): Mus musculus 
2023-06-30 | E-MTAB-13073 | biostudies-arrayexpress
GenomicsTGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
We examined tumours from a large cohort of patients with metastatic urothelial bladder cancer (mUC) treated with an anti–PD-L1 agent (atezolizumab) and identified major determinants of clinical response and immune escape. Whole transcriptome profiles were generated for 368 patients using TruSeq RNA ...
EGAS00001002556 | EGA
ProteomicsCul5 regulates CD4+ T cell fate choice and allergic inflammation
Antigen encounter directs CD4+ T cells to differentiate into T-helper or -regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern -helper versus -regulatory fate remain poorly understood. Here, we show that the E3 ubiquitin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD028492 | Pride
Cis T-cell Asthma Allergy Cul5 Crl5 Cd4 Ubiquitin 
TranscriptomicsRole of TCR:peptide/MHC Class I Affinity in Directing Different Maturation Phenotypes of Dominant and Subdominant Epitope-Specific CD8+ T Cells in Mamu-A*01+ Rhesus Monkeys
CD8+ T cells that bind different regions of proteins derived from a virus are often present at different frequencies. It is thought that those virus-specific CD8+ T cells that are present at the highest frequency are predominantly responsible for control of viral infections. While the number of viru...
ORGANISM(S): Macaca mulatta 
2014-04-24 | E-GEOD-54001 | biostudies-arrayexpress
GenomicsSemiliquidambar cathayensis
Comparative transcriptome analysis of leave, stem, and root tissues of Semiliquidambar cathayensis Hung T. Chang
PRJNA761214 | ENA
TranscriptomicsImpact of aging on cell-to-cell transcriptional variability during immune stimulation
We explored how aging impacts transcriptional dynamics using single-cell RNA-sequencing to profile hundreds of CD4+ T cells from young and old mice from two divergent species. In young animals, immunological challenge drives a conserved transcriptomic switch from highly variable to tightly regulated...
ORGANISM(S): Mus musculus 
2016-07-21 | E-MTAB-4888 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of immune and stromal cells in murine lung cancer
Immune responses against tumor cells depend on T lymphocyte attraction and activity within the tumor microenvironment. Specialized immune-interacting fibroblasts, commonly referred to as fibroblastic reticular cells (FRC), form specialized niches in secondary lymphoid organs, originate from embryoni...
ORGANISM(S): Mus musculus 
2024-11-19 | E-MTAB-13708 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis patients blister cells from skin lesions reveals these consist of cytotoxic T cells annd NK cells
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis; (TEN) are life-threatening adverse drug reactions characterized; by massive epidermal necrosis, in which the specific danger; signals involved remain unclear. Here we show that blister; cells from skin lesions of SJS-TEN primarily consis...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13727 | biostudies-arrayexpress
Sort   by:  
 Page size