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MetabolomicsSupplementing RP-Arg during the gestation and lactation periods of grazing sheep reprograms liver metabolism in offspring lambs by increasing IGF-1 in milk

The nutritional status of ewes during gestation and lactation is a key determinant of lamb growth performance. Supplementing rumen-protected arginine (RP-Arg) during these stages induces maternal metabolic adaptation, thereby maintaining fetal developmental homeostasis. However, the sustained eff...

2025-10-30 | MTBLS13239 | MetaboLights
ProteomicsIdentification of phosphorylation sites in the IGF-1 Receptor
Although Insulin-like Growth Factor (IGF-1) signaling promotes tumor growth and cancer progression, IGF-1 Receptor-targeted therapies have shown poor clinical efficacy. The mechanistic basis for this is unclear as is our understanding of what distinguishes IGF-1R signaling from the closely related I...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017644 | Pride
Tyr1131 Tyr1135 Tyr1136 Igf-1 Tyr125051 Igf-1 receptor 
TranscriptomicsGene expression profile of myeloma cells treated with IGF-1
Objective of this study was to find changes in gene expression of mouse multiple myeloma cells upon treatment with IGF-1 Murine multiple myeloma cells were incubated in serum free medium for 12 hours in the absence (3 replicates) or presence (3 replicates) of 100 ng/ml IGF-1
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-17140 | biostudies-arrayexpress
TranscriptomicsNeurotrophic factors and their receptors are altered by the mere partial IGF-1 deficiency
Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons; playing a role in the maintenance of the synaptic unions, dendrites and axons; also, being crucial for peripheral nervous system development and regulating pl...
ORGANISM(S): Mus musculus 
2018-12-29 | E-MTAB-7508 | biostudies-arrayexpress
GenomicsGenome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells
The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase activity. We report that IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein-1 (SUMO-1) ...
ORGANISM(S): Homo sapiens 
2010-08-25 | E-GEOD-23792 | biostudies-arrayexpress
TranscriptomicsCirculating insulin-like growth factor (IGF)-1 Regulates Hippocampal IGF-1 Levels and Brain Gene Expression During Adolescence
This study, using a growth hormone (GH)-deficient dwarf animal model and peripheral GH replacement, investigated the effects of circulating IGF-1 during adolescence on IGF-1 levels in the brain. Our results demonstrated that hippocampal IGF-1 protein concentrations during adolescence are highly regu...
ORGANISM(S): Rattus norvegicus 
2011-07-20 | E-GEOD-29512 | biostudies-arrayexpress
GenomicsViral Insulin/IGF-like Peptides Inhibit IGF-1 Receptor Signaling to Enhance Viral Replication
Viral Insulin/IGF-like Peptides Inhibit IGF-1 Receptor Signaling to Enhance Viral Replication
PRJNA1285935 | ENA
ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
TranscriptomicsMurine small intestinal crypt cells: IGF-1 stimulated vs. control
microRNA profiling of mouse small intestinal crypt cells comparing control untreated with cells treated with insulin growth factor-1 (IGF-1). IGF-1 stimulated cell proliferation, as observed in Brdu incoporation assay. Two condition experiment. Control vs IGF-1 treatment. Biological replicates: 3 co...
ORGANISM(S): Mus musculus 
2010-11-01 | E-GEOD-20133 | biostudies-arrayexpress
TranscriptomicsDomain-Dependent Effects of Insulin and IGF-1 Receptors on Preadipocyte Gene Expression
Despite a high degree of homology, insulin and IGF-1 receptors (IR/IGF1R) mediate distinct cellular and physiological functions. Here, using chimeric and site-mutated receptors, we demonstrate how domain differences between IR and IGF1R contribute the distinct functions of these receptors. Receptors...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81921 | biostudies-arrayexpress
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