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MetabolomicsMetabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory stimuli either alone or in combination on macropha...
2018-03-13 | MTBLS570 | MetaboLights
TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
ProteomicsImmune Complex-Induced Migration of Slan+ Non-Classical Monocytes
Slan+ Non-Classical Monocytes migrate on immobilized immune complexes. This phenomenon can be blcoked with anti-CD16 blocking antibodies and is therefore thought to be mediated via CD16 (FcyRIII). Nonetheless, other CD16+ cells, such as NK cells or neutrophils, as well as lineage related cells suchs...
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD079927 | Pride
Slanmo Cd16a Immune complexes Fcyriiia Migration Slan+ non-classical monocytes Haptokinesis 
ProteomicsDiscovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics
The goal is to discover novel circulating immune complexes (ICx) in the serum of Lupus Nephritis (LN) as potential biomarkers. Protein A/G magnetic beads or C1q-coated plates were used to capture ICx in the serum of LN, followed by the identification of immunoglobulin-binding proteins using liquid c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031069 | Pride
Human Ms/ms Serum Lupus nephritis 
ProteomicsA proteomics-based method for identifying antigens within immune complexes
A novel approach to recover and identify immune complexes (ICs) was developed using size exclusion chromatography (SEC) and affinity chromatography on immunoglobulin binding columns (HiTrap Protein G). The purification process was monitored by 1D SDS-PAGE, protein staining, Western blotting and, fin...
ORGANISM(S): Betainfluenzavirus Homo sapiens (Human) Alphainfluenzavirus 
2021-01-04 | PXD021575 | Pride
Influenza Immune complexes Human Metaproteomics Orbitrap 
TranscriptomicsGene Expression in Gold Nanoparticle Oligonucleotide Complexes treated Primary Immune Cells
Gold nanoparticle (Au—NP) oligonucleotide complexes hold considerable promise as an approach for manipulating intracellular gene regulation. We show that the uptake and intracellular fate of Au—NP oligonucleotide complexes is associated with endocytosis and signal transduction. A transcriptomeâ€...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-20677 | biostudies-arrayexpress
ProteomicsProteomic Mapping of multifunctional complexes in triatomine Saliva
Salivary multiprotein complexes from Triatoma infestans, Triatoma dimidiata, Dipetalogaster maxima, Rhodnius prolixus, and Rhodnius neglectus were identified by Blue-Native-PAGE (BN-PAGE) coupled with liquid chromatography tandem mass spectrometry.
ORGANISM(S): Triatominae (ncbitaxon:70999) 
2020-03-18 | MSV000085118 | MassIVE
ProteomicsEpitope fine mapping by mass spectrometry: Investigations of immune complexes consisting of monoclonal anti-HpTGEKP antibody and zinc finger protein linker phospho-hexapeptides.
We describe the mass spectrometric analysis of the binding strength of a monoclonal mouse antibody (clone 18E9.D9, BioLegend, London, England) which was raised against the predominantly occuring phosphorylated linker sequence, HpTGEKP, of C2H2 zinc finger proteins (ZNF proteins) using a synthetic ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD031150 | Pride
Item-two Off-line esi-ms Zinc finger-phosphopeptide Antiphosphopeptide-antibody Binding strength characterization 
ProteomicsSerum proteomic analysis of circulating IgA1-containing immune complexes in patients with IgA nephropathy
IgA nephropathy (IgAN) is an autoimmune disease that involves galactose-deficient IgA1 (Gal-deficient IgA1) recognized by autoantibodies to form circulating immune complexes (IgA1-IC). Some of these complexes deposit in the glomeruli and induce kidney injury. Gal-deficient IgA1 alone is not sufficie...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD055562 | Pride
Proteomics Lc-ms Complement Orbitrap Raw Immune complexes Serum Iga nephropathy Glomerular disease 
GenomicsGene Expression of SlanMo migrating on Immune Complexes
Gene Expression of SlanMo migrating on Immune Complexes
PRJNA1480526 | ENA
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