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MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
TranscriptomicsInduction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human B cells; relevance to cellular transformation.
Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by physi...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-45829 | biostudies-arrayexpress
GenomicsImpact of ETV7 activity on interferon-stimulated gene expression in 293T cells treated with interferon alpha
Impact of ETV7 activity on interferon-stimulated gene expression in 293T cells treated with interferon alpha
PRJNA590633 | ENA
GenomicsIschemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia
Ischemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia
PRJNA422107 | ENA
TranscriptomicsGlobal analysis of gene expression by SV40 T antigen in mouse embryo fibroblasts
SV40 large T antigen (TAg) contributes to cell transformation, in part, by targeting two well characterized tumor suppressors, pRb and p53. TAg expression affects the transcriptional circuits controlled by Rb and by p53. We have performed a microarray analysis to examine the global change in gene ex...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-20620 | biostudies-arrayexpress
ProteomicsHomeostatic and Interferon-induced gene expression represent different states of promoter-associated transcription factor ISGF3
Host defense by the innate immune system requires the establishment of antimicrobial states allowing cells to cope with microorganisms before the onset of the adaptive immune response. Interferons (IFN) are of vital importance in the establishment of cell-autonomous antimicrobial immunity. Speed is...
ORGANISM(S): Mus Musculus 
PXD013251 | panorama
ProteomicsLC-MS of FLAG-tagged C-terminal domain of human DUX4
DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNg-induction of MHC Class I and contributes to immune evasion. We show that the DUX4 protein...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD029215 | Pride
Interferon gamma Cgas Dux Interferon beta Rig-i Dux4 Mda5 Stat1 Duxc Interferon stimulated genes 
TranscriptomicsInterferon-stimulated gene expression in STAT1 knockout cells
STAT1 plays a cental role in the induction of interferon-stimulated genes, but interferon alpha can activate a STAT1-independent pathway that leads to gene expression. We performed microarray analysis to examine whether like interferon alpha, interferon lambda, a newly discovered interferon, can ind...
ORGANISM(S): Homo sapiens 
2016-07-22 | GSE84693 | GEO
TranscriptomicsInterferon-stimulated gene expression in STAT1 knockout cells
STAT1 plays a cental role in the induction of interferon-stimulated genes, but interferon alpha can activate a STAT1-independent pathway that leads to gene expression. We performed microarray analysis to examine whether like interferon alpha, interferon lambda, a newly discovered interferon, can ind...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-84693 | biostudies-arrayexpress
GenomicsChronic Interferon Stimulated Gene Transcription Promotes Oncogene Induced Breast Cancer [RNA-Seq]
Chronic Interferon Stimulated Gene Transcription Promotes Oncogene Induced Breast Cancer [RNA-Seq]
PRJNA1032887 | ENA
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