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GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses
This SuperSeries is composed of the following subset Series: GSE36241: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq) GSE37051: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression) Ref...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37052 | biostudies-arrayexpress
ProteomicsExploration of GFP-IRF7 neddylation sites
To explore the possible neddylation sites, GFP-IRF7 and His-NEDD8 were co-overexpressed in HEK293 cell line and GFP was immunoprecipitated, followed by SDS-PAGE and silver staining. The band detected was subjected to LC–MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-19 | PXD024052 | Pride
Hek293 Gfp-irf7 Lc-ms/ms 
ModelsAguilera2017 - Model for IRF7 circuit
Model destription: The model describes the dynamics of murine IRF7 gene expression upon IFN stimulation. The present model comprises known key components and feedback mechanisms. The overall system describes the active IRF7 promoter (Pa) by the binding of IRF7 dimer and ISGF3 to the DNA binding si...
2017-03-17 | MODEL1608100001 | BioModels
TranscriptomicsResponse of IRF7-deficient peripheral blood mononuclear cells to pH1N1 influenza virus infection
IRF7 plays a critical role in the production and amplification of the antiviral type I and III interferon response. Autosomal recessive IRF7-deficiency resulted in life-threatening influenza disease in a 3-year-old child. We studied the impact of IRF7-deficiency in non-hematopoietic tissues (fibrobl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-66486 | biostudies-arrayexpress
GenomicsChIP-seq for IRF7
We performed ChiP-Seq for IRF7 in GM-CSF induced bone-marrow cells. IRF7 ChIP-Seq in myeloid cells
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62697 | biostudies-arrayexpress
GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq)
We predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. Genome-wide location analysis combined with gene deletion studies identified the Irf...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-36241 | biostudies-arrayexpress
ProteomicsIrf7 orchestrates the immunological reaction in cardiomyocytes upon Adar1 deletion
Adenosine deaminases acting on RNA (Adar1 and Adar2) catalyze I-to-A RNA editing, a post-transcriptional mechanism involved in multiple cellular functions. The role of Adar1-dependent RNA editing in cardiomyocytes (CMs) remains unclear. Here we show that conditional deletion of Adar1 in CMs results ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-24 | PXD024974 | Pride
Rna editing Adar1 Cardiomyocytes Immune response Dilated cardiomyopathy Myocarditis Irf7 
TranscriptomicsRNA-seq of human prostate cancer cell line with IRF7 knock-down treated with radiation against wild-type control
Abstract/Project overview Tumour recurrence can be influenced by the mutational status of a tumour but also how the tumour responds to therapy. Whilst activation of Type 1 interferon signalling is a hallmark of how cells respond to viral infection, in cancer cells, multiple stresses are known to a...
ORGANISM(S): Homo sapiens 
2023-07-01 | E-MTAB-9286 | biostudies-arrayexpress
TranscriptomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression)
We have used an unbiased systems approach to predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. We detected significantly increased transc...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37051 | biostudies-arrayexpress
TranscriptomicsRole of IRF7 in airway epithelial cell responses to human rhinovirus infection.
Primary human bronchial epithelial cells were transfected with siRNA to knockdown IRF7 gene expression, allowed to recover, and then infected with human rhinovirus. At 24 hrs post rhinovirus infection, gene expression patterns were profiled on microarrays. The study design consisted of five donors, ...
ORGANISM(S): Homo sapiens 
2016-01-10 | E-GEOD-70190 | biostudies-arrayexpress
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