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MetabolomicsToxoplasma gondii metabolic flexibility in response to iron deprivation

Iron is an essential nutrient for many critical cellular processes. As a consequence of diverse and dynamic host environments, the obligate intracellular parasite Toxoplasma gondii must adapt to iron limited conditions. To investigate the adaptations critical to parasite survival under these cond...

2026-03-18 | MTBLS12831 | MetaboLights
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
MetabolomicsMulti-omics analysis reveals immune-metabolic dysregulation in DNASE1L3-deficient mouse liver

This study investigates the role of DNASE1L3 deficiency in hepatic immune and metabolic regulation. Using transcriptomics, proteomics, and metabolomics, we characterize changes in Kupffer cell polarization, ER stress, iron metabolism, and ferroptosis in DNASE1L3 knockout mice.'

2025-10-25 | MTBLS13057 | MetaboLights
MetabolomicsViral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights
ProteomicsProteomic Investigation of Neurotrophic trans-Banglene Reveals Potential Link to Iron Homeostasis
Neurodegenerative diseases remain an area where the causative disease mechanisms, with few exceptions, are poorly understood and which are very resistant to modern therapeutic advances. Current FDA-approved medications result in modest improvements in quality of life measures and no increase in life...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2024-07-04 | MSV000095252 | MassIVE
ProteomicsIron deficiency causes aspartate-sensitive metabolic dysregulation in CD8+ T-cells
Iron is an irreplaceable co-factor for important enzyme systems, and iron deficiency is the most common micronutrient deficiency worldwide. How iron deprivation influences normal cellular function remains poorly characterised. Using activated CD8+ T-cells as a model for dividing cells we show iron r...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-24 | PXD047814 | Pride
Metabolism Epigenetics Alpha-ketoglutarate Cd8+ t-cell Tca cycle Oxphos Mitochondria Iron Aspartate 
TranscriptomicsUntreated and iron-treated ARPE-19 cell gene expression
To characterize the potential molecular pathway(s) affected by iron treatment and identify the one(s) responsible for C3 induction, we performed a whole genome microarray on untreated ARPE-19 cells and cells treated with 250 ?M FAC for 48h/2d. Gene expression was compared between untreated and FAC-t...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-67603 | biostudies-arrayexpress
UnknownIron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases.
Not available
S-EPMC10848078 | biostudies-literature
UnknownSmoking-induced iron dysregulation in the lung.
Not available
S-EPMC6355389 | biostudies-literature
UnknownDysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation.
Not available
S-EPMC4042101 | biostudies-literature
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