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TranscriptomicsThe role of vimentin in regulating genes related to EMT
To study the biological and functional role of vimentin in maintenance of the mesenchymal phenotype of mammary epithelial cells, vimentin was silenced in the non-transformed MCF10A cells and vimentin-dependent changes in gene expression were analyzed. Scrambled is the siScr-transfected control with ...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-17802 | biostudies-arrayexpress
TranscriptomicsThe effect of aneuploidy on gene expression
Analysis of the gene expression changes observed in aneuploid b1 integrin YYFF MEFs generated as a result of repeated cytokinesis failure compared to tetraploid wild-type MEFs or tetraploid b1YYFF integrin MEFs. The results reveal aneuploidy-specific gene expression changes, both up-and downregulate...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-23729 | biostudies-arrayexpress
ProteomicsAnalysis of Plasma Membrane, Endosomal and Cytoplasmic fractions of mouse embryonic fibroblast
This project aimed to identify novel endosomal proteins and therefore cellular fractionation experiments were performed. Adherent mouse embryonic fibroblast were scraped on ice into hypotonic lysis buffer (10 mM HEPES-KOH pH 7.2, 0.25 M sucrose, 1 mM EDTA, 1 mM MgOAc and protease & phosphatase inhib...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-14 | PXD001870 | Pride
Cytosol Mouse embryonic fibroblasts Endosomes Cell fractionation Plasma membrane 
ProteomicsAdhesion-derived condensates control component availability to regulate adhesion dynamics
Tensins are key components of integrin adhesions and play a key role in linking the actin cytoskeleton with the ECM through interaction with integrin heterodimers. While tensin 1 (TNS1) localises to both focal and fibrillar adhesions, TNS3 has been mostly associated with fibrillar adhesions. Tensins...
ORGANISM(S): Homo sapiens (Human) 
2026-04-24 | PXD069837 | Pride
Protein condensation Integrin adhesions Tensin 3 Phase separation Tensin 1 
ProteomicsGFP-Tensin 1 phosphoproteomics upon sodium arsenite treatment in U2OS cells
Tensin 1 (TNS1) is a key component of integrin adhesion and plays a key role in linking the actin cytoskeleton with the ECM through interaction with integrin heterodimers. TNS1 forms functional and reversible condensates in cells in response to different extracellular stimuli that act as reservoirs ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-24 | PXD069806 | Pride
Phosphorylation Protein condensation Integrin adhesions Phase separation Tensin 1 
ProteomicsEPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
EPLIN, an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain largely unknown and could explain these opposing views. We observed distinct EPLIN isoform localization in breast cancer cells; EPLINα is r...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD052819 | Pride
Bioid Breast cancer Lc-msms Human 
OtherIntegrin endosomal signalling suppresses anoikis.
Data from ProteomeXchange, PXD ID: PXD001870. Experiment: Plasma membrane fraction R2 raw, file: 150120_106.mzml. Published as part of Nat Cell Biol. 2015 Oct 5 . From the Abstract: {{i}} Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell ...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310025155 | GPMDB
Resource Reanalysis 
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