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ProteomicsMAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
MAD2L2 (also known as REV7) functions in a diverse range of processes. It facilitates DNA lesion bypass through translesion synthesis (TLS), aids in interstrand crosslink repair and contributes to timely mitotic progression. Moreover, MAD2L2 plays an important role in DNA repair at DNA double strand...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD026912 | Pride
Mad2l2 Trip13 Dna repair Shieldin Nhej 
GenomicsCandida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34260 | biostudies-arrayexpress
ProteomicsUBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
Maintenance of genome integrity requires tight control of DNA damage signalling and repair activities at DNA lesions, as well as their restriction at telomeres. Key components of the mechanisms underlying appropriate responses to DNA damage include phosphorylation events by DNA damage response (DDR)...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-30 | PXD044410 | Pride
Molecular biology Non-homologous-end joining Rnf168 Dna damage and repair Ube2d3 Lc-msms Telomere 
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