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MetabolomicsIntegrated multi-omics of feces, plasm aand urine can describe and differentiate pediatric active Crohn’s Disease from remission

Background

This study aimed to obtain a holistic view of remission in pediatric Crohn’s Disease (CD) by integrating six omics datasets from three anatomical compartments.


Methods

Patients with fecal calprotectin below 250 mg/kg were c...

2025-07-09 | MTBLS9877 | MetaboLights
Proteomicsozone-derived oxisterols impair lung macrophage phagocytosis via adduction of phagocytosis receptors
Inhalation of the amibient air polution ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B, which can form covalent adducts on cellular ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-18 | PXD019317 | Pride
Lung macrophage Bronchoalveolar lavage Click Secosterol a/b Ozone Human Cd206 
UnknownThe existential dimension of the experience of seclusion: a qualitative study among former psychiatric inpatients.
Not available
S-EPMC10548759 | biostudies-literature
TranscriptomicsGene expression time series of Arabidopsis thaliana Col-0 and rcd1 genotypes in ozone and control
Wild-type Columbia (Col-0) and rcd1-1 seeds were sown on 1:1 peat:vermiculite mixture, stratified for 2 days and grown in controlled environment chambers (Weiss Bio1300; Weiss Gallenkamp, (http://www.weiss-gallenkamp.com/) with 12-h/12-h day/night cycle, temperature 22 C/19 C, relative humidity 70%/...
ORGANISM(S): Arabidopsis thaliana 
2011-06-30 | E-MTAB-662 | biostudies-arrayexpress
ProteomicsMKL1 deficiency results in a neutrophil motility defect with impaired actin polymerization and excessive degranulation
Megakaryoblastic leukemia 1 (MKL1) promotes the regulation of essential cell processes, including actin cytoskeletal dynamics by co-activating serum response factor. Recently, the first human case with MKL1 deficiency has been identified, leading to a novel primary immunodeficiency. We report a seco...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD014633 | Pride
Mkl1 Actin poymerization Neutrophils Srf Mrtf-a 
TranscriptomicsOzone Exposure Alters MicroRNA Expression Profiles in Humans
We set out to test the hypothesis that ozone inhalation exposure significantly alters miRNA expression profiles within the airway of humans. Adult human volunteers were exposed to 0.4 ppm ozone for two hours. Induced sputum samples were collected from each subject 48 hours pre-exposure and 6 hours p...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-47977 | biostudies-arrayexpress
MetabolomicsEVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights
ProteomicsOxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.
Ozone (O3) is a prevalent air pollutant that causes lung inflammation following exposure. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxidized cholesterol products (oxysterols), such as secosterol-A (secoA), which form covalent linkages prefere...
ORGANISM(S): Homo sapiens (Human) 
2021-06-21 | PXD019824 | Pride
Human Lc-msms Airway epithelium Lung inflammasome Alkynylated secosterol Click Protein modification Ozone Secosterols 
MetabolomicsPEROXISOMAL-MITOCHONDRIAL INTERPLAY ALTERATIONS IN SKELETAL MUSCLE RESULT IN EARLY-ONSET SARCOPENIA

Adjustments in muscle mass and metabolic demand are crucial for regulating whole-body metabolism, locomotion, eating, and respiration. Therefore, skeletal muscle is a central influencer of several human diseases. Muscle dysfunction correlates with the onset and progression of several metabolic di...

2025-09-15 | MTBLS12833 | MetaboLights
UnknownAn fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.
Not available
S-EPMC9710544 | biostudies-literature
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