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ProteomicsT cells and adipocyte IL-17RC control fat innervation and thermogenesis
The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation1,2. The molecular basis of this bi-directional communication is unknown. Here we use thermogenic ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-02 | PXD017424 | Pride
Tmt based quantitative proteomics Murine brown adipose tissue 
ProteomicsProteomic analysis of whole brains from Ndufs4-/- mice treated with doxycycline
Mice with mitochondrial complex I deficiency (Ndufs4-/-) suffer from severe energy impairment primarily affecting the brain and die at P55. A small molecule screen developed by our lab using cells harboring human mitochondrial disease mutations identified antibiotics targeting mitochondrial translat...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022860 | Pride
Mitochondrial translation Mouse brain Mitochondrial disease Tetracycline 
ProteomicsDefective NADPH Production in Mitochondrial Disease Complex I Causes Inflammation and Cell Death
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies associated with mitochondrial diseases. However, the pr...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018839 | Pride
Human Mitochondria Tmt Nature communication manuscript: ncomms-19-24220b 
ProteomicsFacultative protein selenation controls redox sensitivity, adipose tissue thermogenesis and obesity
Oxidation of cysteines by reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenols, where sulfur is replaced with selenium, exhibit enhanced reactivity with ROS. Here we developed a mass spectrometric method to interrogate incorporation of selenols ...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018225 | Pride
Ucp1 Thermogenesis Selenium 
ProteomicsProteomic analysis of U2OS cells treated with the dihydroorotate dehydrogenase (DHODH) inhibitor Brequinar
The mitochondrial respiratory chain assembles into higher order complexes termed supercomplexes (SCs) under certain physiological or metabolic stimuli. A small molecule screen developed by the lab identified DHODH inhibitors as potent activators of SC assembly in cancer cells. To investigate the pro...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023882 | Pride
Respirasome Mitochondria Supercomplexes Nucleotides Dihydroorotate dehydrogenase Pyrimidines 
ProteomicsCharacterization of a mitochondria associated phosphocreatine phosphatase in thermogenic adipocytes
Adaptive thermogenesis has attracted much attention because of its ability to raise systemic energy expenditure and counter obesity and diabetes. Recent data have indicated that thermogenic fat cells utilize creatine to stimulate futile substrate cycling, dissipating chemical energy as heat. This mo...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025032 | Pride
Tnap Thermogenesis Obesity Phosphocreatine Adipocyte 
ProteomicsMultiplexed proteomics of a cellular transition from G0 to cell cycle in response to IL-3 activation
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation of these metabolic changes have not been properly e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-21 | MSV000081179 | MassIVE
ProteomicsQuantitative Proteomics of the Cancer Cell Line Encyclopedia
The Cancer Cell Line Encyclopedia (CCLE) is a collaborative effort to generate steady-state large-scale profiling across a collection of nearly a thousand cancer cell lines. Multiple generations of this effort have resulted in a collection of many data types such as RNA expression, mutation annotati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-27 | MSV000085836 | MassIVE
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