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ProteomicsSite-specific K63 ubiquitinomics reveals stabilization of ribosomes in response to oxidative stress
Reprograming of protein synthesis is an essential cellular process to tolerate and resist to stressing conditions. A variety of mechanisms are known to regulate translation at initiation but cells can also control proteins synthesis after the initiation checkpoint. We previously showed that K63 ubiq...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-12-06 | PXD004650 | Pride
Ubiquitinomics Yeast Oxidative stress K63 ubiquitin Translation regulation 
ProteomicsK63 polyubiquitination is a new modulator of the oxidative stress response, shotgun data
Ubiquitination is a post-translational modification that signals multiple processes, including protein degradation, trafficking and DNA repair. Polyubiquitin accumulates globally during the oxidative stress response, and this has been mainly attributed to increased ubiquitin conjugation and perturba...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-01-26 | PXD000960 | Pride
K63 ubiquitination yeast oxidative stress 
ProteomicsUbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains encode signals defining the fates of their modified proteins. Ubiquitin chain-mediated proteasomal degradation is a widespread eukaryotic regulatory mechanism. Yet, heterogeneity of intracellular ubiquitination has precluded systematically comparing degradation capacities of differe...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD060731 | Pride
Ubiquitin K48 Deubiquitination K63 Protein degradation Proteasome Proteostasis Electroporation Ubiquitin code Branched ubiquitin chains 
ProteomicsThe UBA-domain of Ubc1/Ube2K Facilitates the Assembly of K48-/K63-Branched Ubiquitin Chains
Assembly of polymeric ubiquitin (Ub) chains is an essential posttranslational protein modification that regulates widespread intracellular processes in eukaryotic cells. Factors and mechanisms that regulate the formation of Ub chains are key to the understanding of many cellular processes. The E2 en...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-09 | PXD018651 | Pride
Ubc1/ube2k ubiquitin k48-/k63-branched ubiquitin prm 
ProteomicsK63 polyubiquitin targets in the amygdala across the lifespan
K63 polyubiquitin targets in the amygdala across the lifespan
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-18 | PXD058253 | Pride
Amygdala K63 Memory Ubiquitin Aging 
ProteomicsK63 polyubiquitin targets in the hippocampus across the lifespan
K63 polyubiquitin targets in the hippocampus across the lifespan
ORGANISM(S): Rattus norvegicus (Rat) 
2025-06-18 | PXD058248 | Pride
Hippocampus K63 Memory Ubiquitin Aging 
ProteomicsLocalized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress
Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate and supporting stress defenses at several subcellular compartments. However, the rules driving sub...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-04 | MSV000094932 | MassIVE
ProteomicsMARCH1 ubiquitination of MHC II generates a branched K63/K11 ubiquitin chain.
Major histocompatibility class II (MHC II) is critical for adaptive immunity. MHC II intracellular trafficking and degradation is regulated by ubiquitination, with poly-ubiquitination (Ub) of MHC II directing it away from the plasma membrane. The MHC II poly-Ub chain that dictates the fate and funct...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD063057 | Pride
Ubiquitin Mhcii Ub-code Aqua peptides 
ProteomicsThe UBA domain of Ubc1 (Ube2K) Facilitates the Assembly of K48/K63-Branched Ubiquitin Chains
The assembly of a specific polymeric ubiquitin (Ub) chain on a target protein is a key event in the regulation of numerous cellular processes. Yet, the mechanisms that govern the selective synthesis of particular polyubiquitin signals remain enigmatic. The ubiquitin-conjugating (E2) enzymes Ubc1 in ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-02 | PXD022621 | Pride
Ubiquitin Ubc1 Ubc4 Yeast Branched 
ProteomicsK48-K63-Ubiquitin chain pulldown from U2OS cell lysates
SpyTagged branched and unbranched K48- and K63-linked Tetra-Ubiquitin chains were immobilized on SpyCatcher agarose (48Ub4; 63Ub4; [Ub]2-48,63Ub-48Ub; [Ub]2-48,63Ub-63Ub). Pulldown were performed from protease-inhibitor treated U2OS cell lines to identify specific binders of K48-K63-branched Ub4.
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD046025 | Pride
Human Lc-msms Dia Ubiquitin Branched ubiquitin 
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