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ProteomicsTitle: A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
Mammalian SWI/SNF (BAF) chromatin remodeling complexes modulate DNA accessibility and gene expression, however, the mechanisms by which they are targeted on chromatin remain incompletely understood. Here, we define SWIFT (SWI/SNF Ig-Fold for Transcription Factor Interactions), found on the SMARCD fa...
ORGANISM(S): Homo sapiens (Human) 
2025-12-31 | PXD070375 | Pride
ProteomicsIdentification of the SS18-SSX interacting proteins
Using affinity purification determine changes in SS18 BAF complex upon fusion to SSX1. Using soluble nuclear fraction (nuclear extract NE) and nuclease digested chromatin fraction (CHR) we performed affinity capture of proteins bound to wild type SS18 and synovial sarcoma SS18-SSX1 fusion from NE an...
ORGANISM(S): Homo sapiens (Human) 
2020-08-09 | PXD018715 | Pride
Histones Baf complex Nuclear extract 293t cells Synovial sarcoma Chromatin 
UnknownSingle-particle Cryo-EM of the endogenous human BAF complex alone
Not available
EMPIAR-10590 | biostudies-other
ProteomicsA non-canonical SWI/SNF complex underlies synthetic lethality in cancers driven by BAF complex perturbation
Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly characterized non-canonical complex, ncBAF. However, their complex-specific targeting on chromatin, functions and roles in disease remain largely unknown. Here, we...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD011103 | Pride
Brd7 Mswi/snf Chromatin remodeling Brd9 Baf Dpf2 
ProteomicsShifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in endometriod carcinomas
The mammalian SWI/SNF (mSWI/SNF) family of chromatin remodelers govern cell type-specific chromatin accessibility and gene expression and assemble as three distinct complexes: canonical BAF (cBAF), Polybromo-associated BAF (PBAF), and non-canonical BAF (ncBAF). ARID1A and ARID1B are paralog subunits...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD058236 | Pride
Voa1066 Dedifferentiated Cbaf Ncbaf Endometrical carcinoma Ucec Baf An3ca Endometriod carcinoma Pbaf 
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